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Table 4 Hazard ratios (95% CIs) for cardiovascular disease events associated with dyslipidemia and its components

From: Dyslipidemia and cardiovascular disease risk among the MASHAD study population

 

Dyslipidemia

High LDL-C

High TC

High TG

Low HDL-C

Total population

 Total CVD

  Crude HR (95%CI)

1.81 (1.15–2.87)*

1.54 (1.19–2)**

1.53 (1.18–1.98)**

1.57 (1.21–2.03)**

1.15 (0.87–1.52)

  Multivariable HR (95%CI)*

1.14 (0.68–1.89)

1.16 (0.85–1.59)

0.93 (0.68–1.26)

1.13 (0.82–1.55)

0.96 (0.69–1.33)

 MI

  Crude HR (95%CI)

2.12 (0.65–6.89)

1.91 (1.03–3.55)*

2 (1.07–3.73)*

1.77 (0.95–3.30)

1.08 (0.56–2.10)

  Multivariable HR (95%CI)*

1.90 (0.44–8.07)

1.65 (0.83–3.30)

1.46 (0.72–2.95)

1.52 (0.75–3.09)

0.80 (0.38–1.66)

 SA

  Crude HR (95%CI)

1.24 (0.62–2.49)

1.52 (0.96–2.41)

1.73 (1.10–2.73)*

1.50 (0.95–2.37)

1.23 (0.75–2.02)

  Multivariable HR (95%CI)*

0.90 (0.40–2.04)

1.10 (0.61–1.97)

1.02 (0.57–1.81)

1.14 (0.63–2.05)

1 (0.55–1.83)

 UA

  Crude HR (95%CI)

2.37 (1.15–4.85)

1.43 (0.99–2.06)

1.31 (0.92–1.89)

1.58 (1.10–2.26)

1.14 (0.77–1.68)

  Multivariable HR (95%CI)*

1.16 (0.55–2.43)

1.03 (0.66–1.61)

0.73 (0.47–1.14)

1.01 (0.65–1.57)

1.01 (0.63–1.62)

Men

 Total CVD

  Crude HR (95%CI)

1.43 (0.84–2.43)

1.37 (0.93–2.03)

1.36 (0.93–1.99)

1.40 (0.96–2.05)

1.01 (0.69–1.48)

  Multivariable HR (95%CI)*

0.95 (0.53–1.71)

1.13 (0.71–1.81)

1 (0.63–1.59)

1.49 (0.94–2.35)

0.90 (0.57–1.41)

 MI

  Crude HR (95%CI)

1.81 (0.54–6.03)

1.86 (0.84–4.10)

2.46 (1.12–5.43)*

2.19 (0.99–4.82)

1.02 (0.46–2.24)

  Multivariable HR (95%CI)*

1.95 (0.45–8.51)

2.22 (0.94–5.26)

2.71 (1.12–6.57)*

2.35 (0.94–5.86)

0.85 (0.36–2.04)

 SA

  Crude HR (95%CI)

0.86 (0.35–2.12)

1 (0.44–2.28)

1.14 (0.52–2.49)

1.38 (0.64–2.94)

1 (0.47–2.13)

  Multivariable HR (95%CI)*

0.58 (0.20–1.66)

0.66 (0.22–2.03)

0.62 (0.22–1.75)

1.48 (0.56–3.91)

0.83 (0.33–2.11)

 UA

  Crude HR (95%CI)

1.75 (080–3.87)

1.38 (0.81–2.37)

1.13 (0.66–1.93)

1.16 (0.68–1.97)

1.02 (0.61–1.72)

  Multivariable HR (95%CI)*

0.91 (0.40–2.11)

1.01 (0.51–1.98)

0.71 (0.36–1.39)

1.18 (0.62–2.24)

0.95 (0.50–1.81)

Women

 Total CVD

  Crude HR (95%CI)

3.71 (1.37–10.04)*

1.74 (1.22–2.48)**

1.75 (1.23–2.50)**

1.70 (1.19–2.42)**

1.52 (0.97–2.38)

  Multivariable HR (95%CI)*

1.95 (0.61–6.24)

1.19 (0.77–1.82)

0.83 (0.53–1.28)

0.80 (0.51–1.25)

1.12 (0.67–1.89)

 MI

  Crude HR (95%CI)

_¤

2.23 (0.81–6.14)

1.67 (0.60–4.60)

1.08 (0.37–3.16)

2.42 (0.55–10.74)

  Multivariable HR (95%CI)*

_¤

1.31 (0.40–4.26)

0.72 (0.21–2.41)

0.67 (0.21–2.20)

1.14 (0.24–5.49)

 SA

  Crude HR (95%CI)

1.84 (0.57–5.93)

1.87 (1.06–.31)*

2.16 (1.20–3.86)*

1.61 (0.90–2.87)

1.38 (0.68–2.77)

  Multivariable HR (95%CI)*

1.38 (0.32–5.92)

1.30 (0.64–2.67)

1.18 (0.57–2.46)

0.92 (0.43–1.97)

1.08 (0.47–2.45)

 UA

  Crude HR (95%CI)

7.55 (1.05–54.46)*

1.51 (0.91–2.49)

1.56 (0.95–2.57)

2.03 (1.23–3.4)**

1.52 (0.81–2.86)

  Multivariable HR (95%CI)*

2.75 (0.37–20.22)

1.06 (0.57–1.94)

0.66 (0.36–1.21)

0.77 (0.41–1.43)

1.20 (0.57–2.55)

  1. Abbreviations: CVD cardiovascular disease, MI myocardial infarction, SA stable angina, UA unstable angina, HR hazard ratio, CI confidence interval
  2. Dyslipidemia was defined as total cholesterol ≥200, or triglycerides ≥150, or low-density lipoprotein cholesterol (LDL-C) ≥130, or high-density lipoprotein cholesterol (HDL-C) < 40 (for men) and HDL-C < 50 (for women)
  3. *Multivariable HRs were adjusted for age, body mass index (BMI), family history of cardiovascular disease, smoking status (non-smoker, ex-smoker and current smoker), lipid lowering drug, anti-hypertensive drug, diabetes mellitus, hypertension, HEI, and total energy intake
  4. ¤ There was no MI event in this category
  5. * P-value< 0.05, ** P-value< 0.01, *** P-value< 0.001
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Lipids in Health and Disease

ISSN: 1476-511X