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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Bioinformatics analysis of vascular RNA-seq data revealed hub genes and pathways in a novel Tibetan minipig atherosclerosis model induced by a high fat/cholesterol diet

Fig. 2

Identifying DEGs by transcriptome sequencings and functional analysis. a The volcano plots of DEGs in the atherosclerosis/NC gene set. The red dots represented up-regulated genes, and the blue ones represented down-regulated genes, and the gray ones showed no significance. b The numbers of DEGs up-regulated and down-regulated in the atherosclerosis/NC group. c Two-way hierarchical clustering heatmap of up-regulated and down-regulated DEGs in the atherosclerosis/NC group. d The enrichment maps of GO biological processes (FDR q value < 0.01, p-value< 0.005) display the enriched genes-sets between atherosclerosis and NC by g: profiler online tool, the red nodes indicates up-regulated DEGs, the green indicates down-regulated DEGs. e The KEGG pathway analysis (FDR q value < 0.01) of up-regulated and down-regulated DEGs in the atherosclerosis/NC group by KOBAS 3.0 online analysis database. f Hallmark gene sets enriched in the atherosclerosis/NC group by GSEA (FDR q value< 0.05). g GSEA enrichment plots for six hallmark gene sets enriched in the atherosclerosis/NC group

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