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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Bioinformatics analysis of vascular RNA-seq data revealed hub genes and pathways in a novel Tibetan minipig atherosclerosis model induced by a high fat/cholesterol diet

Fig. 4

Major PPI networks of DEGs and module analysis. a Centrality analysis of the initial PPI network. Venn diagram showing nodes with highest values (above of the average) for each centrality parameter considered (Degree, Betweenness, and eigenvector). b Major PPI networks of DEGs and MCODE analysis. Module 1: score = 18.235, module 2: score = 15.259, module 3: score = 8.188; module 4: score = 4.087. Diamond represents a hub gene. Circles sizes represent a degree. Gray arrows indicate a connection between genes. c The major PPI network of top 15 hub genes and transcription factor determination shows SPI1 or NFĸB-1 to be important regulators of the top 15 hub genes. Node color reflects the degree of connectivity. Red color represents the highest degree, green color represents a transcription factor

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Lipids in Health and Disease

ISSN: 1476-511X