Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice

Table 2 Protective effects of MEM on Serum Lipid Profile

Treatments	Total Cholesterol (mg/dl)	Triglycerides (U/L)	HDL (mg/dl)	LDL (mg/dl)
Control	62.37 ± 2.61	54.43 ± 0.74	40.77 ± 2.27	29.1 ± 3.19
RIPE	98.10 ± 1.25^****	134.09 ± 3.35^****	22.78 ± 2.41 ^****	59.18 ± 1.79^****
MEM (200 mg/kg) + RIPE	80.77 ± 2.98^****++++	72.91 ± 5.93^****++++	31.80 ± 1.09**^++++##	44.31 ± 1.27^****++++
MEM (400 mg/kg) + RIPE	77.40 ± 3.74^****++++	67.81 ± 1.17^****++++	38.78 ± 2.43⁺⁺⁺⁺	33.37 ± 3.69⁺⁺⁺⁺
Vit B6 + RIPE	70.91 ± 2.69^****++++	63.30 ± 3.07**⁺⁺⁺⁺	39.01 ± 1.39⁺⁺⁺⁺	34.01 ± 2.07⁺⁺⁺⁺
Vit B6	63.98 ± 1.37⁺⁺⁺⁺	55.79 ± 0.73⁺⁺⁺⁺	41.01 ± 1.59⁺⁺⁺⁺	28.02 ± 0.31⁺⁺⁺⁺
MEM (400 mg/kg)	65.80 ± 1.11⁺⁺⁺⁺	59.37 ± 5.14⁺⁺⁺⁺	42.11 ± 0.94⁺⁺⁺⁺	29.11 ± 3.11⁺⁺⁺⁺

Values are Mean ± SD (06 number). RIPE, Rifampicin (13.5 mg/kg), Isoniazid (6.75 mg/kg), Pyrazinamide (36.0 mg/kg) and Ethambutol (24.8 mg/kg). MEM, M. royleanus leaves methanol extract. *, **, *** indicate significance from the control group at p < 0.05, p < 0.01 and p < 0.0001 probability level, +, ++, +++ indicate significance from the RIPE group at p < 0.05, p < 0.01 and p < 0.0001, while ### indicate significance of MEM (400 mg/kg) + RIPE group vs MEM (200 mg/kg) + RIPE group at p < 0.0001 probability level (One-way ANOVA followed by Tukey’s multiple comparison tests)

ISSN: 1476-511X