Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice

Table 3 Protective effects of MEM on liver marker enzymes in serum of mice

Group	AST (U/l)	ALT (U/l)	ALP (U/l)	γ-GT (U/l)	LDH (U/l)
Control	94.17 ± 3.41	70.46 ± 2.35	142.87 ± 4.65	1.84 ± 0.43	45.34 ± 1.61
RIPE	204.9 ± 6.11^****	211.2 ± 5.13^****	306.47 ± 6.68^****	4.01 ± 0.75^****	141.8 ± 4.17^****
MEM (200 mg/kg) + RIPE	170.29 ± 6.38^****++++####	169.9 ± 4.28^****++++####	252.14 ± 5.31^****++++####	2.98 ± 0.24^*+	110.5 ± 3.68^****++++####
MEM (400 mg/kg) + RIPE	121.15 ± 4.28_****++++	123.0 ± 2.24^****++++	172.13 ± 3.20^****++++	2.16 ± 0.12⁺⁺⁺⁺	73.26 ± 2.34^****++++
Vit B6 + RIPE	109.62 ± 4.4^****++++	98.13 ± 3.13^****++++	161.15 ± 3.98^****++++	2.34 ± 0.57⁺⁺⁺⁺	72.1 ± 2.75^****++++
Vit B6 alone	98.26 ± 4.89⁺⁺⁺⁺	68.14 ± 2.81⁺⁺⁺⁺	143.66 ± 3.63⁺⁺⁺⁺	1.98 ± 0.46⁺⁺⁺⁺	44.32 ± 2.23⁺⁺⁺⁺
MEM (400 mg/kg) alone	93.73 ± 4.36⁺⁺⁺⁺	69.58 ± 2.63⁺⁺⁺⁺	144.35 ± 5.87⁺⁺⁺⁺	1.93 ± 0.79⁺⁺⁺⁺	47.16 ± 1.49⁺⁺⁺⁺

Values are Mean ± SD (06 number). RIPE, Rifampicin (13.5 mg/kg), Isoniazid (6.75 mg/kg), Pyrazinamide (36.0 mg/kg) and Ethambutol (24.8 mg/kg). MEM, M. royleanus leaves methanol extract. Vit B6, Vitamin B6. *, **, *** indicate significance from the control group at p < 0.05, p < 0.01 and p < 0.0001 probability level, +, ++, +++ indicate significance from the RIPE group at p < 0.05, p < 0.01 and p < 0.0001, while ### indicate significance of MEM (400 mg/kg) + RIPE group vs MEM (200 mg/kg) + RIPE group at p < 0.0001 probability level (One-way ANOVA followed by Tukey’s multiple comparison tests)

ISSN: 1476-511X