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Table 3 Association between the MALAT1 polymorphisms and risk of IS

From: A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

SNPs

Controls

n = 320 (n%)

IS patient

n = 316 (n%)

AOR† (95%CI)

P† value

rs600231

    

AA

117 (36.6)

120 (38.0)

1.000 (ref)

 

AG

151 (47.2)

154 (48.7)

0.987 (0.651–1.496)

0.950

GG

52 (16.2)

42 (13.3)

0.778 (0.434–1.395)

0.399

Dominant

  

0.933 (0.629–1.386)

0.733

Recessive

  

1.276 (0.750–2.171)

0.369

A

385 (60.2)

394 (62.3)

1.000 (ref)

 

G

255 (39.8)

238 (37.7)

0.906 (0.688–1.192)

0.481

rs1194338

    

CC

154 (48.1)

188 (59.5)

1.000 (ref)

 

AC

135 (42.2)

106 (33.5)

0.623 (0.417–0.932)

0.021

AA

31 (9.7)

22 (7.0)

0.474 (0.226–0.991)

0.047

Dominant

  

0.596 (0.406–0.874)

0.008

Recessive

  

1.721 (0.841–3.523)

0.137

C

443 (69.2)

482 (76.3)

1.000 (ref)

 

A

197 (30.8)

150 (23.7)

0.658 (0.487–0.890)

0.007

rs4102217

    

GG

243 (75.9)

237 (75.0)

1.000 (ref)

 

CG

73 (22.8)

69 (21.8)

1.186 (0.753–1.868)

0.463

CC

4 (1.3)

10 (3.2)

2.322 (0.605–8.906)

0.219

Dominant

  

1.254 (0.807–1.947)

0.314

Recessive

  

0.452 (0.119–1.721)

0.244

G

559 (87.3)

543 (85.9)

1.000 (ref)

 

C

81(12.7)

89 (14.1)

1.280 (0.869–1.886)

0.212

rs591291

    

CC

123 (38.5)

129 (40.8)

1.000 (ref)

 

CT

147 (45.9)

144 (45.6)

0.916 (0.607–1.384)

0.678

TT

50 (15.6)

43 (13.6)

0.752 (0.421–1.343)

0.336

Dominant

  

0.873 (0.592–1.289)

0.495

Recessive

  

1.268 (0.743–2.163)

0.384

C

393 (61.4)

402 (63.6)

1.000 (ref)

 

T

247 (38.6)

230 (36.4)

0.877 (0.665–1.155)

0.350

  1. IS Ischemic stroke, OR Odds ratio, 95% CI, 95% confidence interval, † Adjusted by age, gender, hypertension, diabetes mellitus, smoker, TCH, TG, HDL-C, LDL-C, Apo-A1, Apo-B, NEFA