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Table 1 Genome-wide association studies and detailed information of single nucleotide polymorphisms used as instrumental variable in the Mendelian randomization analyses of lifestyle factors in relation to cardiovascular diseases

From: Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis

TraitsSNPEthnicsChrPositionNearest geneEAEAFBETASESample sizeP valueStudyReferenceJournal
Sedentary behavioursrs26579Europeans587,985,295MEF2C-AS2G0.4150.0280.00591,1052.60 × 10− 09UK BiobankAiden Doherty et al.,201828Nat Commun
Sedentary behavioursrs25966Europeans5106,822,908EFNA5G0.5310.0280.00591,1053.00 × 10− 09UK BiobankAiden Doherty et al.,201828Nat Commun
Sedentary behavioursrs6801032Europeans368,527,135LOC105377146A0.2590.0310.00591,1053.10 × 10−09UK BiobankAiden Doherty et al.,201828Nat Commun
Sedentary behavioursrs7779206Europeans771,723,883CALN1A0.5580.0280.00591,1054.20 × 10−09UK BiobankAiden Doherty et al.,201828Nat Commun
MVPArs429358Europeans1945,411,941APOET0.850−0.0190.003377,2347.30 × 10−11UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
MVPArs7804463Europeans7133,447,651EXOC4T0.5300.0130.002377,2344.10 × 10−10UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
MVPArs2854277Europeans632,628,084HLA-DQB1C0.9200.0270.005377,2341.40 × 10−08UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
MVPArs1379183Europeans750,237,784C7orf72/SPATA48C0.410−0.0120.002377,2341.70 × 10−08UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
MVPArs3094622Europeans630,327,952RPP21A0.8600.0180.003377,2341.00 × 10−08UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
MVPArs149943Europeans628,002,388ZNF165G0.8500.0160.003377,2345.60 × 10−08UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
MVPArs2035562Europeans385,056,521CADM2A0.330−0.0140.002377,2341.00 × 10−09UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
MVPArs7854466Europeans937,044,388PAX5T0.560−0.0140.002377,2342.40 × 10−11UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
MVPArs1043595Europeans7128,410,012CALUG0.7200.0130.002377,2344.20 × 10−08UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
VPArs1248860Europeans385,015,779CADM2G0.480−0.0510.007261,0555.30 × 10−15UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
VPArs2764261Europeans6108,927,842FOXO3A0.3700.0300.005261,0555.30 × 10−08UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
VPArs13243553Europeans7133,506,955EXOC4G0.6100.0390.007261,0552.40 × 10−09UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
VPArs3781411Europeans10126,715,436CTBP2C0.8800.0580.009261,0551.00 × 10−10UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
VPArs328902Europeans735,020,843DPY19L1C0.690−0.0410.006261,0551.30 × 10−10UK BiobankKlimentidis YC et al.,201827Int J Obes (Lond)
Sleep durationrs1191685Europeans2113,811,454PAX8C0.3702.8700.47044,5631.06 × 10−09CHARGEDaniel J. Gottlieb et al,201529Mol Psychiatry
Sleep durationrs1823125Europeans2113,806,882PAX8G0.2603.0100.50045,2811.71 × 10−08CHARGEDaniel J. Gottlieb et al,201529Mol Psychiatry
Sleep durationrs1807282Europeans2113,826,506PAX8T0.2602.8900.49046,8053.91 × 10−09CHARGEDaniel J. Gottlieb et al,201529Mol Psychiatry
Sleep durationrs1964463Europeans2113,785,491PAX8G0.2502.8400.50045,2811.07 × 10−08CHARGEDaniel J. Gottlieb et al,201529Mol Psychiatry
Sleep durationrs4587207Europeans630,874,924IER3G0.800−3.1400.56046,8072.02 × 10−08CHARGEDaniel J. Gottlieb et al,201529Mol Psychiatry
Sleep durationrs4248149Europeans630,875,606IER3C0.800−3.0800.56046,8103.95 × 10−08CHARGEDaniel J. Gottlieb et al,201529Mol Psychiatry
Sleep durationrs2394403Europeans630,875,848IER3T0.800−3.0700.56046,8114.39 × 10−08CHARGEDaniel J. Gottlieb et al,201529Mol Psychiatry
  1. SNP single nucleotide polymorphism; Chr chromosome; EA effect allele; EAF effect allele frequency; SE standard error; MVPA moderate-to-vigorous physical activity; VPA vigorous physical activity; CHARGE the Cohorts for Heart and Aging Research in Genomic Epidemiology