Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis

Zhuang, Zhenhuang; Gao, Meng; Yang, Ruotong; Li, Nan; Liu, Zhonghua; Cao, Weihua; Huang, Tao

doi:10.1186/s12944-020-01257-z

Lipids in Health and Disease

Table 1 Genome-wide association studies and detailed information of single nucleotide polymorphisms used as instrumental variable in the Mendelian randomization analyses of lifestyle factors in relation to cardiovascular diseases

From: Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis

Traits	SNP	Ethnics	Chr	Position	Nearest gene	EA	EAF	BETA	SE	Sample size	P value	Study	Reference	Journal
Sedentary behaviours	rs26579	Europeans	5	87,985,295	MEF2C-AS2	G	0.415	0.028	0.005	91,105	2.60 × 10^− 09	UK Biobank	Aiden Doherty et al.,2018²⁸	Nat Commun
Sedentary behaviours	rs25966	Europeans	5	106,822,908	EFNA5	G	0.531	0.028	0.005	91,105	3.00 × 10^− 09	UK Biobank	Aiden Doherty et al.,2018²⁸	Nat Commun
Sedentary behaviours	rs6801032	Europeans	3	68,527,135	LOC105377146	A	0.259	0.031	0.005	91,105	3.10 × 10⁻⁰⁹	UK Biobank	Aiden Doherty et al.,2018²⁸	Nat Commun
Sedentary behaviours	rs7779206	Europeans	7	71,723,883	CALN1	A	0.558	0.028	0.005	91,105	4.20 × 10⁻⁰⁹	UK Biobank	Aiden Doherty et al.,2018²⁸	Nat Commun
MVPA	rs429358	Europeans	19	45,411,941	APOE	T	0.850	−0.019	0.003	377,234	7.30 × 10⁻¹¹	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
MVPA	rs7804463	Europeans	7	133,447,651	EXOC4	T	0.530	0.013	0.002	377,234	4.10 × 10⁻¹⁰	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
MVPA	rs2854277	Europeans	6	32,628,084	HLA-DQB1	C	0.920	0.027	0.005	377,234	1.40 × 10⁻⁰⁸	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
MVPA	rs1379183	Europeans	7	50,237,784	C7orf72/SPATA48	C	0.410	−0.012	0.002	377,234	1.70 × 10⁻⁰⁸	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
MVPA	rs3094622	Europeans	6	30,327,952	RPP21	A	0.860	0.018	0.003	377,234	1.00 × 10⁻⁰⁸	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
MVPA	rs149943	Europeans	6	28,002,388	ZNF165	G	0.850	0.016	0.003	377,234	5.60 × 10⁻⁰⁸	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
MVPA	rs2035562	Europeans	3	85,056,521	CADM2	A	0.330	−0.014	0.002	377,234	1.00 × 10⁻⁰⁹	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
MVPA	rs7854466	Europeans	9	37,044,388	PAX5	T	0.560	−0.014	0.002	377,234	2.40 × 10⁻¹¹	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
MVPA	rs1043595	Europeans	7	128,410,012	CALU	G	0.720	0.013	0.002	377,234	4.20 × 10⁻⁰⁸	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
VPA	rs1248860	Europeans	3	85,015,779	CADM2	G	0.480	−0.051	0.007	261,055	5.30 × 10⁻¹⁵	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
VPA	rs2764261	Europeans	6	108,927,842	FOXO3	A	0.370	0.030	0.005	261,055	5.30 × 10⁻⁰⁸	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
VPA	rs13243553	Europeans	7	133,506,955	EXOC4	G	0.610	0.039	0.007	261,055	2.40 × 10⁻⁰⁹	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
VPA	rs3781411	Europeans	10	126,715,436	CTBP2	C	0.880	0.058	0.009	261,055	1.00 × 10⁻¹⁰	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
VPA	rs328902	Europeans	7	35,020,843	DPY19L1	C	0.690	−0.041	0.006	261,055	1.30 × 10⁻¹⁰	UK Biobank	Klimentidis YC et al.,2018²⁷	Int J Obes (Lond)
Sleep duration	rs1191685	Europeans	2	113,811,454	PAX8	C	0.370	2.870	0.470	44,563	1.06 × 10⁻⁰⁹	CHARGE	Daniel J. Gottlieb et al,2015²⁹	Mol Psychiatry
Sleep duration	rs1823125	Europeans	2	113,806,882	PAX8	G	0.260	3.010	0.500	45,281	1.71 × 10⁻⁰⁸	CHARGE	Daniel J. Gottlieb et al,2015²⁹	Mol Psychiatry
Sleep duration	rs1807282	Europeans	2	113,826,506	PAX8	T	0.260	2.890	0.490	46,805	3.91 × 10⁻⁰⁹	CHARGE	Daniel J. Gottlieb et al,2015²⁹	Mol Psychiatry
Sleep duration	rs1964463	Europeans	2	113,785,491	PAX8	G	0.250	2.840	0.500	45,281	1.07 × 10⁻⁰⁸	CHARGE	Daniel J. Gottlieb et al,2015²⁹	Mol Psychiatry
Sleep duration	rs4587207	Europeans	6	30,874,924	IER3	G	0.800	−3.140	0.560	46,807	2.02 × 10⁻⁰⁸	CHARGE	Daniel J. Gottlieb et al,2015²⁹	Mol Psychiatry
Sleep duration	rs4248149	Europeans	6	30,875,606	IER3	C	0.800	−3.080	0.560	46,810	3.95 × 10⁻⁰⁸	CHARGE	Daniel J. Gottlieb et al,2015²⁹	Mol Psychiatry
Sleep duration	rs2394403	Europeans	6	30,875,848	IER3	T	0.800	−3.070	0.560	46,811	4.39 × 10⁻⁰⁸	CHARGE	Daniel J. Gottlieb et al,2015²⁹	Mol Psychiatry

SNP single nucleotide polymorphism; Chr chromosome; EA effect allele; EAF effect allele frequency; SE standard error; MVPA moderate-to-vigorous physical activity; VPA vigorous physical activity; CHARGE the Cohorts for Heart and Aging Research in Genomic Epidemiology

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