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Table 5 Grading of Recommendations Assessment, Development and Evaluation (GRADE) according to Schünemann 2009 [20]

From: What is the impact of the adjunctive use of omega-3 fatty acids in the treatment of periodontitis? A systematic review and meta-analysis

Quality assessmentSummary of findingsImportance
No of patientsEffectQuality
No of studiesDesign (Randomized controlled trial)LimitationsInconsistencyIndirectnessImprecisionOther considerationsOmega 3ControlSMD
[95% Conf. Interval]
PD after 3 months
5Yesno serious limitationsno serious inconsistencyano indirectnessserious imprecisionnone132133−3.931
[−4.446,-3.417]
moderatehigh
CAL after 3 months
5Yesno serious limitationsno serious inconsistencyano indirectnessserious imprecisionnone132133−3.521
[−3.982,-3.059]
moderatehigh
BOP after 3 months
1Yesno serious limitationsno serious inconsistencyno indirectnessvery serious imprecisionnone4040n/alowlow
  1. athe missing possible positive effect in reduction of PD and CAL could be due to low number of participants in Martinez et al. 2014 [31] and low-dose application of omega-3 in Keskiner et al. 2017 [32], SMD Standardized mean difference