Table 1 Demographic and clinical characteristics of ischemic stroke patients receiving rtPA or not receiving rtPA. Results for continuous variables are presented as Mean ± SD, while discrete data are presented as percentage frequency. Pearson’s Chi-Square is used to compare differences between demographic and clinical characteristics in rtPA treated groups
From: Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients
Characteristic | No rtPA group | rtPA group | P-value |
|---|---|---|---|
Number of patients | 4142 | 1327 | |
Age Group: No. (%) | |||
  < 50 | 467 (11.3) | 191 (14.4) | 0.001*a |
 50–59 | 736 (17.8) | 260 (19.6) |  |
 60–69 | 981 (23.7) | 318 (24.0) |  |
 70–79 | 942 (22.7) | 289 (21.8) |  |
  > =80 | 1016 (24.5) | 269 (20.3) |  |
 Mean ± SD | 67.7 ± 14.7 | 65.8 ± 14.8 | <.001*b |
Race: No (%) | |||
 White | 3228 (77.9) | 1060 (79.9) | 0.313 |
 Black | 774 (18.7) | 228 (17.2) |  |
 Other | 140 (3.4) | 39 (2.9) |  |
Gender: No. (%) | |||
 Female | 1994 (48.1) | 668 (50.3) | 0.163 |
 Male | 2148 (51.9) | 659 (49.7) |  |
Hispanic Ethnicity: No. (%) | 55 (1.3) | 30 (2.3) | 0.017*a |
BMI: Mean ± SD | 28.18 ± 7.01 | 28.84 ± 6.84 | 0.003*b |
Medical History: No. (%) | |||
 Atrial Fib | 713 (17.2) | 211 (15.9) | 0.266 |
 Coronary Artery Disease | 1262 (30.5) | 399 (30.1) | 0.782 |
 Carotid Artery Stenosis | 278 (6.7) | 56 (4.2) | 0.001*a |
 Depression | 516 (12.5) | 205 (15.4) | 0.005*a |
 Diabetes | 1520 (36.7) | 415 (31.3) | < 0.001*a |
 Drugs or Alcohol | 260 (6.3) | 77 (5.8) | 0.532 |
 Dyslipidemia | 2055 (49.6) | 700 (52.8) | 0.047*a |
 Stroke Family History | 364 (8.8) | 130 (9.8) | 0.265 |
 Heart Failure | 453 (10.9) | 137 (10.3) | 0.531 |
 Hormonal Replacement Therapy | 48 (1.2) | 31 (2.3) | 0.002*a |
 Hypertension | 3262 (78.8) | 1044 (78.7) | 0.95 |
 Migraine | 89 (2.1) | 45 (3.4) | 0.011*a |
 Obesity | 1633 (39.4) | 678 (51.1) | < 0.001*a |
 Previous Stroke | 1134 (27.4) | 290 (21.9) | < 0.001*a |
 Previous TIA (>  24 h) | 334 (8.1) | 143 (10.8) | 0.002*a |
 Prosthetic Heart Valve | 52 (1.3) | 10 (0.8) | 0.133 |
 Peripheral Vascular Disease | 321 (7.7) | 79 (6.0) | 0.029*a |
 Chronic Renal Disease | 368 (8.9) | 79 (6.0) | 0.001*a |
 Sickle Cell | 4 (0.1) | 0 (0.0) | 0.257 |
 Sleep Apnea | 125 (3.0) | 45 (3.4) | 0.495 |
 Smoker | 1098 (26.5) | 388 (29.2) | 0.052 |
Medication History: No (%) | |||
 HTN medication | 2851 (68.8) | 943 (71.1) | 0.125 |
 Cholesterol Reducer | 1796 (43.4) | 632 (47.6) | 0.006*a |
 Diabetes medication | 1164 (28.1) | 331 (24.9) | 0.025*a |
 Antidepressant | 489 (11.8) | 222 (16.7) | < 0.001*a |
Initial NIHSS Score: No (%) | |||
 0–9 | 2556 (76.3) | 733 (59.4) | < 0.001*a |
 10–14 | 308 (9.2) | 199 (16.1) |  |
 15–20 | 308 (9.2) | 193 (15.6) |  |
 21–25 | 180 (5.4) | 110 (8.9) |  |
 Mean ± SD | 7.43 ± 8.11 | 10.55 ± 8.18 | < 0.001*b |
Lab values: Mean ± SD | |||
 Total cholesterol | 173.01 ± 53.6 | 168.66 ± 46.48 | 0.006*b |
 Triglycerides | 139.25 ± 104.13 | 140.71 ± 107.94 | 0.674 |
 HDL | 41.77 ± 13.91 | 41.8 ± 13.65 | 0.946 |
 LDL | 105.39 ± 42.06 | 102.52 ± 39.07 | 0.029*b |
 Lipids | 6.64 ± 2.83 | 6.25 ± 1.6 | < 0.001*b |
 Blood Glucose | 149.22 ± 82.86 | 141.29 ± 74.84 | 0.001*b |
 Serum Creatinine | 1.34 ± 1.27 | 1.14 ± 0.75 | < 0.001*b |
 Initial Platelet Count | 36,527.8 ± 87,310.62 | 174,859.69 ± 128,632.87 | < 0.001*b |
 INR | 1.17 ± 0.57 | 1.06 ± 0.15 | < 0.001*b |
Vital Signs: Mean ± SD | |||
 Heart Rate | 82.07 ± 18.94 | 81.81 ± 17.18 | 0.644 |
 Blood Pressure Systolic | 151.99 ± 30.04 | 151.31 ± 26.92 | 0.439 |
 Blood Pressure Diastolic | 82.29 ± 19.38 | 82.92 ± 18.3 | 0.277 |
Ambulation Status Prior to Event: No. (%) | |||
 Ambulate Independently | 3628 (87.6) | 1259 (94.9) | < 0.001*a |
 Ambulate with Assistance | 180 (4.3) | 23 (1.7) |  |
 Unable to Ambulate | 193 (4.7) | 20 (1.5) |  |
 Not Documented | 140 (3.4) | 25 (1.9) |  |
Ambulation Status on Admission: No. (%) | |||
 Ambulate Independently | 1099 (26.5) | 232 (17.5) | < 0.001*a |
 Ambulate with Assistance | 1320 (31.9) | 306 (23.1) |  |
 Unable to Ambulate | 1249 (30.2) | 479 (36.1) |  |
 Not Documented | 474 (11.4) | 310 (23.4) |  |
Ambulation Status on Discharge: No. (%) | |||
 Ambulate Independently | 1516 (36.6) | 658 (49.6) | < 0.001*a |
 Ambulate with Assistance | 1466 (35.4) | 354 (26.7) |  |
 Unable to Ambulate | 847 (20.4) | 222 (16.7) |  |
 Not Documented | 19 (0.5) | 4 (0.3) |  |
First Care Received: No. (%) | |||
 Emergency Department | 3285 (80.1) | 1012 (76.6) | 0.006*a |
 Direct Admission | 815 (19.9) | 309 (23.4) |  |
Improved Ambulation: No. (%) | 1141 (29.7) | 684 (55.3) | < 0.001*a |
NIHSS > 7: No. (%) | 1177 (33.5) | 690 (52.4) | < 0.001*a |