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Table 1 Tryptophan and kynurenine pathway metabolites in plasma after 14 days of 0.9% TTP diet in C57BL/6 male mice (n = 6)

From: Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio

  Control 0.9% TTP  
Mean ± SD Mean ± SD P -value
Trp (μM) 114.9 ± 5.92 144.4 ± 1.81 0.0147
Kyn (μM) 1.2 ± 0.02 1.3 ± 0.01 0.0346
Neopt (nM) 1.7 ± 0.10 2.1 ± 0.21 0.2182
AA (nM) 138.5 ± 7.84 83.5 ± 4.96 0.0069
HAA (nM) 21.8 ± 5.06 7.7 ± 0.24 0.0490
KA (nM) 150.9 ± 29.0 48.3 ± 5.19 0.0406
XA (nM) 147.3 ± 21.0 34.3 ± 0.48 0.0095
HK (nM) 86.3 ± 29.6 44.3 ± 14.0 0.1410
QA (nM) 291.0 ± 24.3 223.5 ± 48.8 0.3410
Nam (μM) 2.60 ± 0.37 4.49 ± 0.19 0.0160
  1. Abbreviations: AA Anthranilic acid, HAA 3-hydroxyanthranilic acid, HK 3-hydroxykynurenine, KA Kynurenic acid, Kyn Kynurenine, Neopt Neopterin, Nam Nicotinamide, QA Quinolinic acid, Trp Tryptophan, XA Xanthurenic acid