Skip to main content
Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Cigarette smoke exposure impairs lipid metabolism by decreasing low-density lipoprotein receptor expression in hepatocytes

Fig. 4

Expression of LDLR protein in mouse liver and HepG2 cells. a Expression of LDLR in the liver tissue of the mice in each group. b HepG2 cells were stimulated with different concentrations of CSE for 24 h and cell viability was measured using a CCK-8 kit. c HepG2 cells were stimulated with CSE at various concentrations (0, 1, 2.5, 5%) for 24 h, and that at 2.5 and 5% CSE markedly inhibited the cellular expression of LDLR protein compared with the control cells. d 5% CSE reduced cellular LDLR protein levels in HepG2 cells in a time-dependent manner. e Melatonin reversed the downregulation of LDLR protein expression in HepG2 cells induced by CSE. *P < 0.05, **P < 0.001

Back to article page