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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: The imbalance in the aortic ceramide/sphingosine-1-phosphate rheostat in ovariectomized rats and the preventive effect of estrogen

Fig. 1

Comparative analysis of S1P signaling between the SHAM group, the OVX group, and the OVX + E group. a and b: expression of SphK at mRNA (n = 4) and protein (n = 4 for SphK1, n = 3 for SphK2) levels respectively; c: the content of aortic S1P between groups (n = 6); d content of aortic C1P between groups (n = 6); e and f: expression of S1P receptors at the mRNA (n = 4) and protein (n = 4 for S1P1, n = 5 for S1P2, n = 3 for S1P3) levels respectively. SphK: sphingosine kinase; S1P: sphingosine-1-phosphate; S1P1/2/3: sphingosine-1-phosphate receptor 1/2/3; SHAM group: sham-operated group; OVX group: ovariectomized group; OVX + E group: OVX group treated with estradiol valerate. Data presented as mean ± standard deviation. * P < 0.05, ** P < 0.01, *** P < 0.001

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