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Table 3 Fatty acid profile and estimated desaturase activity in metabolically healthy and unhealthy subjects

From: Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health

Fatty acids, %FAME Metabolically healthy (n = 150) Metabolically unhealthy (n = 52) P
C12:0 0.12 (0.1, 0.14) 0.14 (0.12, 0.17) 0.169
C14:0 0.91 (0.85, 0.98) 1.16 (1.06, 1.25) < 0.001
C15:0 0.25 (0.24, 0.26) 0.25 (0.23, 0.26) 0.658
C16:0 21.51 (21.25, 21.78) 22.35 (21.95, 22.76) 0.001
C17:0 0.35 (0.34, 0.36) 0.33 (0.32, 0.35) 0.049
C18:0 11.79 (11.62, 11.96) 10.98 (10.72, 11.24) < 0.001
C20:0 0.09 (0.08, 0.09) 0.09 (0.09, 0.1) 0.167
SFA total 35.03 (34.72, 35.34) 35.3 (34.84, 35.77) 0.323
C16:1 n7 1.36 (1.26, 1.46) 1.72 (1.57, 1.86) < 0.001
C18:1 n9 19.85 (19.45, 20.24) 22.51 (21.9, 23.11) < 0.001
C18:1 c11 1.54 (1.49, 1.59) 1.51 (1.44, 1.59) 0.512
C20:1 n9 0.26 (0.24, 0.27) 0.24 (0.22, 0.26) 0.221
MUFA total 23 (22.55, 23.45) 25.98 (25.3, 26.66) < 0.001
SCD16 0.06 (0.06, 0.07) 0.08 (0.07, 0.08) < 0.001
SCD18 1.7 (1.64, 1.75) 2.08 (2, 2.16) < 0.001
D5D 0.01 (0.01, 0.01) 0.01 (0.01, 0.01) 0.081
D6D 5.87 (5.65, 6.09) 5.14 (4.8, 5.48) < 0.001
C18:2 n6 19.81 (19.34, 20.29) 18.94 (18.22, 19.66) 0.042
C18:3 n6 0.2 (0.18, 0.22) 0.22 (0.19, 0.24) 0.257
C18:3 n3 0.49 (0.46, 0.52) 0.61 (0.56, 0.66) < 0.001
C20:3 n6 1.4 (1.35, 1.45) 1.38 (1.31, 1.46) 0.694
C20:4 n6 8.03 (7.77, 8.29) 7.01 (6.61, 7.4) < 0.001
C20:5 n3 1.48 (1.33, 1.63) 1.06 (0.83, 1.29) 0.002
C22:5 n3 1.39 (1.34, 1.44) 1.21 (1.13, 1.28) < 0.001
C22:6 n3 3.4 (3.25, 3.56) 2.98 (2.74, 3.21) 0.003
PUFA total 36.21 (35.63, 36.79) 33.4 (32.52, 34.28) < 0.001
ω-3 total 6.77 (6.46, 7.08) 5.85 (5.37, 6.33) 0.001
ω-6 total 29.44 (28.91, 29.98) 27.55 (26.74, 28.35) < 0.001
  1. P values from linear regression models adjusted for age and sex. Values are estimated marginal means 95% confidence interval). P is significant at 0.05 level. SCD1, Stearoyl-CoA desaturase-1; D5D, delta-5-desaturase; D6D, delta-6-desaturase; SFA, saturated fatty acids; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids