Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

Liu, Shou-Sheng; Ma, Xue-Feng; Zhao, Jie; Du, Shui-Xian; Zhang, Jie; Dong, Meng-Zhen; Xin, Yong-Ning

doi:10.1186/s12944-020-01288-6

Lipids in Health and Disease

Table 2 Summary studies for the association between NAFLD and colorectal adenomas or colorectal cancer

From: Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

Study	Country	Sample size	NAFLD diagnosis	Patients source	Date	Study design	Colorectal cancer diagnosis	Adjusted confounding factors	Study quality
Chen et al. 2018 [26]	China	764	Ultrasonography	Community	2014–2016	Cross-sectional	Colonoscopy	Age, sex, smoking, alcohol intake, metabolic syndrome	Good
Ahn et al. 2017 [25]	South Korea	26,540	Ultrasonography	Community	2003–2012	Cross-sectional	Histology	Age, sex, BMI, smoking, alcohol intake, first degree family history of colorectal cancer, aspirin use, fasting plasma glucose, total cholesterol, triglycerides, systolic blood pressure, use of any hypoglycemic, anti-hypertensive drugs or use of statin	Good
Chen et al. 2017 [47]	China	3686	Ultrasonography	Hospital	2007–2014	Cross-sectional	Endoscopy	Age, CEA, stage, tumor location, and tumor differentiation	Good
Pan et al. 2017 [31]	China	1793	Ultrasonography	Community	2011–2015	Cross-sectional	Colonoscopy	Age, sex, ALT, uric acid, metabolic syndrome	Good
Lee et al. 2016 [28]	South Korea	44,221	Ultrasonography	Community	2010–2011	Cross-sectional	Colonoscopy	Age, sex, BMI, smoking, family history of colorectal cancer, aspirin use, hypertension, diabetes mellitus	Good
Lin et al. 2014 [30]	China	2314	Ultrasonography	Hospital	2007–2011	Cross-sectional	Colonoscopy	Age, sex, BMI, hypertension, plasma triglycerides, uric acid, ALT, albumin, hemoglobin, platelet count	Fair
Wong et al. 2011 [36]	China	380	¹H-MRS/Liver biopsy	Community/Hospital	2008–2010	Cross-sectional	Colonoscopy	Age, sex, BMI, smoking, family history of colorectal cancer, hypertension, diabetes mellitus	Good
Stadlmayr et al. 2011 [35]	Austria	1211	Ultrasonography	Hospital	2007–2009	Cross-sectional	Colonoscopy	Age, sex, BMI, glucose intolerance status (impaired fasting glycaemia or diabetes mellitus)	Good
Hwang et al. 2010 [34]	South Korea	2917	Ultrasonography	Hospital	2007	Cross-sectional	Colonoscopy	Age, sex, smoking, hypertension, diabetes mellitus, metabolic syndrome	Good
Allen et al. 2019 [21]	USA	276	HCIDA/ICD-9	Community	1997–2016	Cohort	ICD-9	NA	Good
Hamaguchi et al. 2019 [27]	Japan	15,926	Ultrasonography	Community	2004–2016	Cohort	Endoscopy	Sex, age and lifestyle factors including smoking habits, alcoholic consumption and physical activities and diabetes	Good
Kim et al. 2017 [24]	South Korea	NA	Ultrasonography	Community	2004–2005	Cohort	Pathology	Demographic and metabolic factors	Good
Yang et al. 2017 [32]	South Korea	882	Ultrasonography/ computed tomography	Hospital	2009–2013	Cohort	Colonoscopy	Age, sex, smoking, hypertension, diabetes mellitus, use of aspirin or lipid-lowering agents; imaging for diagnosis of NAFLD	Fair
Huang et al. 2013 [33]	South Korea	1522	Ultrasonography	Hospital	2003–2010	Cohort	Colonoscopy	Age, sex, BMI, smoking, hypertension, diabetes mellitus, metabolic syndrome	Fair
Lee et al. 2012 [29]	South Korea	5517	Ultrasonography	Hospital	2002–2006	Cohort	Colonoscopy	Age, BMI, smoking, hypertension, dyslipidemia, fasting glucose level	Fair

Abbreviation: HICDA Hospital International Classification of Diseases Adapted, ICD International Classification of Diseases

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ISSN: 1476-511X

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