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Table 2 Lipid profile of patients before initiation of any hypolipidemic treatment

From: Achieving low-density lipoprotein cholesterol targets as assessed by different methods in patients with familial hypercholesterolemia: an analysis from the HELLAS-FH registry

Parameter Adults Children
At diagnosis
(n = 1423)
On treatment
(n = 966)
At diagnosis
(n = 197)
On treatment
(n = 117)
Total cholesterol, mg/dL
(mmol/L)
318 ± 80
(8.2 ± 2.1)
228 ± 75§
(5.9 ± 1.9)
305 ± 64
(7.9 ± 1.7)
253 ± 98§
(6.5 ± 2.5)
Triglycerides, mg/dL
(mmol/L)
130 (97–181)
[1.5 (1.1–2.0)]
111 (80–157)§
[1.3 (0.9–1.8)]§
68 (59–89)
[0.8 (0.7–1.0)]
111 (80–157)
[1.3 (0.9–1.8)]
HDL-C, mg/dL
(mmol/L)
51 ± 17
(1.3 ± 0.4)
51 ± 17
(1.3 ± 0.4)
57 ± 15
(1.5 ± 0.4)
51 ± 17
(1.3 ± 0.4)
non-HDL-C, mg/dL
(mmol/L)
267 ± 81
(6.9 ± 2.1)
176 ± 75§
(4.6 ± 1.9)
248 ± 66
(6.4 ± 1.7)
176 ± 75§
(4.6 ± 1.9)§
LDL-CF, mg/dL
(mmol/L)
235 ± 70
(6.1 ± 1.8)
150 ± 71§
(3.9 ± 1.8)
233 ± 65
(6.0 ± 1.7)
183 ± 97§
(4.7 ± 2.5)§
LDL-CM/H, mg/dL
(mmol/L)
235 ± 69
(6.1 ± 1.8)
151 ± 70§
(3.9 ± 1.8)
229 ± 65
(5.9 ± 1.7)
180 ± 97§
(4.7 ± 2.5)§
aLDL-CLp(a)corM/H, mg/dL
(mmol/L)
211 ± 61
(5.5 ± 1.6)
121 ± 62†,§
(3.1 ± 1.6)
225 ± 70
(5.8 ± 1.8)
174 ± 94†,§
(4.5 ± 2.4)§
aLp(a), mg/dL
(nmol/L)
21 (9–56)
[42.0 (15.8–118.3)]
20 (9–55)
[42.0 (15.8–118.3)]
15 (8–50)
[28.9 (13.6–105)]
20 (10–60)
[39.8 (18.0–127.0)]
aApolipoprotein AI, mg/dL
(g/L)
143 ± 35
(1.4 ± 0.4)
144 ± 25
(1.4 ± 0.3)
140 ± 24
(1.4 ± 0.2)
144 ± 25
(1.4 ± 0.3)
aApolipoprotein B, mg/dL
(g/L)
156 ± 65
(1.6 ± 0.7)
110 ± 35§
(1.1 ± 0.4)
147 ± 36
(1.5 ± 0.4)
110 ± 35§
(1.1 ± 0.4)§
  1. Data are presented as mean ± standard deviation or median (interquartile range) for parametric and non-parametric variables, respectively
  2. HDL-C High-density lipoprotein cholesterol, LDL-CF Low-density lipoprotein cholesterol as calculated by the Friedewald formula, LDL-CM/H low-density lipoprotein cholesterol as calculated by the Marin/Hopkins formula, LDL-CLp(a)corM/H Corrected for Lp(a) levels low-density lipoprotein cholesterol as calculated by the Marin/Hopkins formula, Lp(a) was converted using the formula: Lp(a) nmol/L = 2.18 × Lp(a) mg/dL − 3.83
  3. : P < 0.001 vs LDL-CF, §P < 0.001 vs diagnosis
  4. a: Data available for 355 patients