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Table 1 Meta-analysis of the ADRB3 Trp64Arg polymorphism with adipokines levels

From: The Trp64Arg polymorphism in β3 adrenergic receptor (ADRB3) gene is associated with adipokines and plasma lipids: a systematic review, meta-analysis, and meta-regression

Groups or subgroups Comparisons (Subjects) SMD (95% CI) PHeterogeneity PSMD
Leptin
 All 33 (4999) 0.14 (0.02–0.26) < 0.001 0.02
 Studies in HWE 31 (4594) 0.12 (0.00–0.24) < 0.001 0.05
 Caucasian 19 (3036) 0.11 (− 0.06–0.28) < 0.01 0.21
 Asian 11 (1124) 0.18 (0.03–0.33) 0.18 0.02
 Female 9 (1416) 0.11 (−0.18–0.41) < 0.001 0.46
 Male 9 (1161) 0.22 (0.02–0.42) 0.04 0.03
 Obesity 19 (2418) 0.08 (−0.09–0.24) 0.01 0.36
 Healthy subjects 12 (2384) 0.19 (0.00–0.38) < 0.001 0.05
Adiponectin
 All 12 (2073) −0.28 (−0.53--0.02) < 0.001 0.03
 Studies in HWE 11 (1800) − 0.26 (− 0.39--0.13) < 0.001 < 0.001
 Caucasian 10 (1545) − 0.08 (− 0.23–0.07) 0.64 0.28
 Asian 2 (528) −0.86 (−1.05--0.66) 0.95 < 0.001
 Obesity 10 (1545) − 0.08 (− 0.23–0.07) 0.64 0.28
  1. ADRB3: beta3-adrenergic receptor gene, SMD: standardized mean difference, 95% CI: 95% confidence interval, HWE Hardy-Weinberg equilibrium