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Table 2 Meta-analysis of the ADRB3 Trp64Arg polymorphism with adipokines levels after excluding the study with heterogeneity

From: The Trp64Arg polymorphism in β3 adrenergic receptor (ADRB3) gene is associated with adipokines and plasma lipids: a systematic review, meta-analysis, and meta-regression

Groups or subgroups Comparisons (Subjects) SMD (95% CI) PHeterogeneity PSMD
Leptin
 All 29 (4581) 0.17 (0.09–0.24) 0.08 < 0.001
 Studies in HWE 27 (4176) 0.14 (0.06–0.23) 0.07 < 0.001
 Caucasian 16 (2733) 0.16 (0.05–0.27) 0.46 0.01
 Asian 10 (1009) 0.24 (0.11–0.37) 0.80 < 0.001
 Female 7 (1253) −0.02 (− 0.17–0.12) 0.05 0.76
 Male 8 (1046) 0.30 (0.16–0.44) 0.52 < 0.001
 Obesity 16 (2113) 0.10 (−0.02–0.22) 0.83 0.11
 Healthy subjects 11 (2271) 0.19 (0.09–0.30) 0.06 < 0.001
Adiponectin
 All 8 (1190) − 0.63 (− 0.78--0.48) 0.07 < 0.001
 Studies in HWE 7 (917) −0.52 (− 0.70--0.34) 0.10 < 0.001
 Caucasian 6 (662) −0.26 (− 0.50--0.02) 0.68 0.03
 Asian 2 (528) −0.86 (−1.05--0.66) 0.95 < 0.001
 Obesity 6 (662) −0.08 (− 0.23–0.07) 0.64 0.28
  1. ADRB3 beta3-adrenergic receptor gene, SMD standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium