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Table 2 Meta-analysis of the ADRB3 Trp64Arg polymorphism with adipokines levels after excluding the study with heterogeneity

From: The Trp64Arg polymorphism in β3 adrenergic receptor (ADRB3) gene is associated with adipokines and plasma lipids: a systematic review, meta-analysis, and meta-regression

Groups or subgroups

Comparisons (Subjects)

SMD (95% CI)

PHeterogeneity

PSMD

Leptin

 All

29 (4581)

0.17 (0.09–0.24)

0.08

< 0.001

 Studies in HWE

27 (4176)

0.14 (0.06–0.23)

0.07

< 0.001

 Caucasian

16 (2733)

0.16 (0.05–0.27)

0.46

0.01

 Asian

10 (1009)

0.24 (0.11–0.37)

0.80

< 0.001

 Female

7 (1253)

−0.02 (− 0.17–0.12)

0.05

0.76

 Male

8 (1046)

0.30 (0.16–0.44)

0.52

< 0.001

 Obesity

16 (2113)

0.10 (−0.02–0.22)

0.83

0.11

 Healthy subjects

11 (2271)

0.19 (0.09–0.30)

0.06

< 0.001

Adiponectin

 All

8 (1190)

− 0.63 (− 0.78--0.48)

0.07

< 0.001

 Studies in HWE

7 (917)

−0.52 (− 0.70--0.34)

0.10

< 0.001

 Caucasian

6 (662)

−0.26 (− 0.50--0.02)

0.68

0.03

 Asian

2 (528)

−0.86 (−1.05--0.66)

0.95

< 0.001

 Obesity

6 (662)

−0.08 (− 0.23–0.07)

0.64

0.28

  1. ADRB3 beta3-adrenergic receptor gene, SMD standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium
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Lipids in Health and Disease

ISSN: 1476-511X