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Table 3 Meta-analysis of the ADRB3 Trp64Arg polymorphism with plasma lipid levels

From: The Trp64Arg polymorphism in β3 adrenergic receptor (ADRB3) gene is associated with adipokines and plasma lipids: a systematic review, meta-analysis, and meta-regression

Groups or subgroups Comparisons (Subjects) SMD (95% CI) PHeterogeneity PSMD
TG
 All 162 (43,778) 0.07 (0.03–0.11) < 0.001 < 0.001
 Studies in HWE 142 (38,507) 0.05 (0.02–0.09) < 0.001 0.01
 Caucasian 47 (17,065) 0.09 (0.02–0.16) < 0.01 < 0.01
 Asian 101 (24,424) 0.06 (0.02–0.11) < 0.01 < 0.01
 Chilean 3 (340) 0.04 (−0.41–0.50) 0.02 0.85
 Brazilian 2 (223) 0.22 (−0.13–0.57) 0.37 0.22
 Indonesian 4 (531) −0.18 (− 0.45–0.09) 0.84 0.20
 Other ethnic 5 (1195) 0.14 (−0.16–0.45) < 0.01 0.35
 Female 40 (10,329) 0.06 (0.01–0.11) 0.01 0.01
 Male 30 (9499) 0.03 (−0.02–0.08) < 0.01 0.30
 Obesity 38 (5772) 0.12 (0.05–0.18) 0.32 < 0.01
 T2DM 20 (4335) 0.03 (− 0.01–0.07) < 0.001 0.07
 Hypertension 4 (781) −0.05 (− 0.22–0.13) 0.28 0.61
 CAD 7 (1225) −0.12 (− 0.25–0.01) 0.46 0.07
 Healthy subjects 69 (25,873) 0.05 (0.00–0.10) < 0.001 0.03
 Children 14 (2337) 0.12 (−0.05–0.29) < 0.001 0.16
TC
 All 162 (49,738) 0.04 (0.01–0.07) < 0.001 0.01
 Studies in HWE 140 (43,716) 0.03 (0.01–0.05) < 0.001 0.01
 Caucasian 46 (19,238) 0.07 (0.00–0.13) < 0.01 0.04
 Asian 104 (27,572) 0.02 (0.00–0.05) < 0.001 0.05
 Chilean 3 (340) 0.04 (−0.19–0.27) 0.83 0.73
 Brazilian 4 (1310) 0.09 (−0.06–0.24) 0.52 0.23
 Other ethnic 5 (1278) 0.00 (−0.27–0.27) < 0.01 0.98
 Female 38 (11,568) 0.06 (0.02–0.11) 0.23 0.01
 Male 29 (9543) −0.00 (− 0.08–0.08) < 0.01 0.92
 Obesity 36 (5400) 0.07 (0.00–0.13) 0.32 0.04
 T2DM 20 (5257) 0.04 (−0.02–0.11) 0.75 0.22
 Hypertension 6 (1182) 0.04 (− 0.10–0.18) 0.57 0.54
  CAD 7 (1225) −0.11 (− 0.27–0.06) 0.28 0.20
 Healthy subjects 68 (27,441) 0.05 (0.01–0.10) < 0.001 0.02
 Children 14 (2279) 0.03 (−0.13–0.20) < 0.01 0.67
LDL-C
 All 103 (25,965) 0.03 (−0.02–0.07) < 0.001 0.24
 Studies in HWE 86 (21,459) −0.01 (− 0.05–0.04) 0.01 0.82
 Caucasian 29 (7687) 0.01 (−0.06–0.07) 0.07 0.88
 Asian 64 (15,264) 0.04 (−0.02–0.09) < 0.001 0.22
 Brazilian 4 (1310) 0.02 (− 0.35–0.38) 0.02 0.94
 Other ethnic 5 (1338) 0.07 (−0.17–0.30) 0.01 0.59
 Female 24 (5800) 0.05 (− 0.02–0.11) 0.30 0.17
 Male 19 (3140) −0.04 (− 0.17–0.08) 0.01 0.51
 Obesity 30 (4930) 0.01 (−0.06–0.08) 0.36 0.81
 T2DM 10 (2345) 0.17 (− 0.06–0.40) < 0.001 0.14
 CAD 6 (1040) −0.05 (− 0.18–0.09) 0.87 0.51
 Healthy subjects 39 (12,149) 0.05 (−0.02–0.12) < 0.001 0.20
 Children 11 (2080) 0.10 (−0.09–0.30) < 0.001 0.30
HDL-C
 All 164 (49,069) −0.05 (− 0.08--0.02) < 0.001 < 0.01
 Studies in HWE 144 (43,919) −0.04 (− 0.07--0.01) < 0.001 0.03
 Caucasian 45 (17,720) −0.06 (− 0.08--0.04) 0.60 0.05
 Asian 102 (27,648) −0.05 (− 0.09--0.01) < 0.001 0.02
 Chilean 3 (340) −0.10 (− 0.33–0.13) 0.37 0.38
 Brazilian 4 (1310) − 0.14 (− 0.33–0.04) 0.62 0.22
 Indonesian 4 (531) −0.07 (− 0.34–0.20) 0.52 0.59
 Other ethnic 4 (613) −0.32 (− 0.58--0.07) 0.13 0.01
 Female 40 (12,250) − 0.04 (− 0.08--0.00) 0.22 0.05
 Male 31 (9407) −0.01 (− 0.08–0.07) 0.01 0.91
 Obesity 36 (5310) −0.06 (− 0.10--0.02) < 0.01 0.04
 T2DM 19 (3575) − 0.17 (− 0.30--0.04) < 0.01 0.01
 Hypertension 4 (957) 0.01 (− 0.15–0.16) 0.10 0.91
 CAD 8 (1532) −0.14 (− 0.37–0.09) 0.01 0.23
 Healthy subjects 72 (27,600) −0.00 (− 0.03–0.03) 0.16 0.93
 Children 15 (2409) −0.09 (− 0.18–0.00) 0.06 0.06
  1. ADRB3 beta3-adrenergic receptor gene, SMD standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium, TG triglycerides, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, CAD coronary artery disease, T2DM type 2 diabetes mellitus