Table 3 Meta-analysis of the ADRB3 Trp64Arg polymorphism with plasma lipid levels
Groups or subgroups | Comparisons (Subjects) | SMD (95% CI) | PHeterogeneity | PSMD |
|---|---|---|---|---|
TG | ||||
All | 162 (43,778) | 0.07 (0.03–0.11) | < 0.001 | < 0.001 |
Studies in HWE | 142 (38,507) | 0.05 (0.02–0.09) | < 0.001 | 0.01 |
Caucasian | 47 (17,065) | 0.09 (0.02–0.16) | < 0.01 | < 0.01 |
Asian | 101 (24,424) | 0.06 (0.02–0.11) | < 0.01 | < 0.01 |
Chilean | 3 (340) | 0.04 (−0.41–0.50) | 0.02 | 0.85 |
Brazilian | 2 (223) | 0.22 (−0.13–0.57) | 0.37 | 0.22 |
Indonesian | 4 (531) | −0.18 (− 0.45–0.09) | 0.84 | 0.20 |
Other ethnic | 5 (1195) | 0.14 (−0.16–0.45) | < 0.01 | 0.35 |
Female | 40 (10,329) | 0.06 (0.01–0.11) | 0.01 | 0.01 |
Male | 30 (9499) | 0.03 (−0.02–0.08) | < 0.01 | 0.30 |
Obesity | 38 (5772) | 0.12 (0.05–0.18) | 0.32 | < 0.01 |
T2DM | 20 (4335) | 0.03 (− 0.01–0.07) | < 0.001 | 0.07 |
Hypertension | 4 (781) | −0.05 (− 0.22–0.13) | 0.28 | 0.61 |
CAD | 7 (1225) | −0.12 (− 0.25–0.01) | 0.46 | 0.07 |
Healthy subjects | 69 (25,873) | 0.05 (0.00–0.10) | < 0.001 | 0.03 |
Children | 14 (2337) | 0.12 (−0.05–0.29) | < 0.001 | 0.16 |
TC | ||||
All | 162 (49,738) | 0.04 (0.01–0.07) | < 0.001 | 0.01 |
Studies in HWE | 140 (43,716) | 0.03 (0.01–0.05) | < 0.001 | 0.01 |
Caucasian | 46 (19,238) | 0.07 (0.00–0.13) | < 0.01 | 0.04 |
Asian | 104 (27,572) | 0.02 (0.00–0.05) | < 0.001 | 0.05 |
Chilean | 3 (340) | 0.04 (−0.19–0.27) | 0.83 | 0.73 |
Brazilian | 4 (1310) | 0.09 (−0.06–0.24) | 0.52 | 0.23 |
Other ethnic | 5 (1278) | 0.00 (−0.27–0.27) | < 0.01 | 0.98 |
Female | 38 (11,568) | 0.06 (0.02–0.11) | 0.23 | 0.01 |
Male | 29 (9543) | −0.00 (− 0.08–0.08) | < 0.01 | 0.92 |
Obesity | 36 (5400) | 0.07 (0.00–0.13) | 0.32 | 0.04 |
T2DM | 20 (5257) | 0.04 (−0.02–0.11) | 0.75 | 0.22 |
Hypertension | 6 (1182) | 0.04 (− 0.10–0.18) | 0.57 | 0.54 |
CAD | 7 (1225) | −0.11 (− 0.27–0.06) | 0.28 | 0.20 |
Healthy subjects | 68 (27,441) | 0.05 (0.01–0.10) | < 0.001 | 0.02 |
Children | 14 (2279) | 0.03 (−0.13–0.20) | < 0.01 | 0.67 |
LDL-C | ||||
All | 103 (25,965) | 0.03 (−0.02–0.07) | < 0.001 | 0.24 |
Studies in HWE | 86 (21,459) | −0.01 (− 0.05–0.04) | 0.01 | 0.82 |
Caucasian | 29 (7687) | 0.01 (−0.06–0.07) | 0.07 | 0.88 |
Asian | 64 (15,264) | 0.04 (−0.02–0.09) | < 0.001 | 0.22 |
Brazilian | 4 (1310) | 0.02 (− 0.35–0.38) | 0.02 | 0.94 |
Other ethnic | 5 (1338) | 0.07 (−0.17–0.30) | 0.01 | 0.59 |
Female | 24 (5800) | 0.05 (− 0.02–0.11) | 0.30 | 0.17 |
Male | 19 (3140) | −0.04 (− 0.17–0.08) | 0.01 | 0.51 |
Obesity | 30 (4930) | 0.01 (−0.06–0.08) | 0.36 | 0.81 |
T2DM | 10 (2345) | 0.17 (− 0.06–0.40) | < 0.001 | 0.14 |
CAD | 6 (1040) | −0.05 (− 0.18–0.09) | 0.87 | 0.51 |
Healthy subjects | 39 (12,149) | 0.05 (−0.02–0.12) | < 0.001 | 0.20 |
Children | 11 (2080) | 0.10 (−0.09–0.30) | < 0.001 | 0.30 |
HDL-C | ||||
All | 164 (49,069) | −0.05 (− 0.08--0.02) | < 0.001 | < 0.01 |
Studies in HWE | 144 (43,919) | −0.04 (− 0.07--0.01) | < 0.001 | 0.03 |
Caucasian | 45 (17,720) | −0.06 (− 0.08--0.04) | 0.60 | 0.05 |
Asian | 102 (27,648) | −0.05 (− 0.09--0.01) | < 0.001 | 0.02 |
Chilean | 3 (340) | −0.10 (− 0.33–0.13) | 0.37 | 0.38 |
Brazilian | 4 (1310) | − 0.14 (− 0.33–0.04) | 0.62 | 0.22 |
Indonesian | 4 (531) | −0.07 (− 0.34–0.20) | 0.52 | 0.59 |
Other ethnic | 4 (613) | −0.32 (− 0.58--0.07) | 0.13 | 0.01 |
Female | 40 (12,250) | − 0.04 (− 0.08--0.00) | 0.22 | 0.05 |
Male | 31 (9407) | −0.01 (− 0.08–0.07) | 0.01 | 0.91 |
Obesity | 36 (5310) | −0.06 (− 0.10--0.02) | < 0.01 | 0.04 |
T2DM | 19 (3575) | − 0.17 (− 0.30--0.04) | < 0.01 | 0.01 |
Hypertension | 4 (957) | 0.01 (− 0.15–0.16) | 0.10 | 0.91 |
CAD | 8 (1532) | −0.14 (− 0.37–0.09) | 0.01 | 0.23 |
Healthy subjects | 72 (27,600) | −0.00 (− 0.03–0.03) | 0.16 | 0.93 |
Children | 15 (2409) | −0.09 (− 0.18–0.00) | 0.06 | 0.06 |