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Table 6 A summary of hub genes

From: Ubiquitin-specific protease as the underlying gene biomarker for aortic stenosis

SymbolDescriptionFuntion
RANRAN, member RAS oncogene familyGO:0035281 pre-miRNA export from nucleus
hsa03008: Ribosome biogenesis in eukaryotes
hsa03013: RNA transport
CCT7chaperonin containing TCP1 subunit 7GO:1904871 positive regulation of protein localization to Cajal body
GO:1904869 regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
CSE1Lchromosome segregation 1 likeGO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0051170 import into nucleus
SNRPD3small nuclear ribonucleoprotein D3 polypeptideGO:0000387 spliceosomal snRNP assembly
GO:0008334 histone mRNA metabolic process
hsa03040: Spliceosome
TUBA1Atubulin alpha 1aGO:0097711 ciliary basal body-plasma membrane docking
hsa04540: Gap junction;
hsa04210: Apoptosis
USP14ubiquitin specific peptidase 14GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1904293 negative regulation of ERAD pathway
PSMD9proteasome 26S subunit, non-ATPase 9GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0046676 negative regulation of insulin secretion
CDK4cyclin dependent kinase 4GO:1904637 cellular response to ionomycin; 12-myristate
GO:1904628 cellular response to phorbol 13-acetate
GO:1904636 response to ionomycin
RPL23Aribosomal protein L23aGO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006613 cotranslational protein targeting to membrane
hsa03010: Ribosome
XRCC6X-ray repair cross complementing 6GO:0075713 establishment of integrated proviral latency
GO:0097680 double-strand break repair via classical nonhomologous end joining
hsa03450: Non-homologous end-joining
EIF2S1eukaryotic translation initiation factor 2 subunit alphaGO:1990737 response to manganese-induced endoplasmic reticulum stress
GO:0032057 negative regulation of translational initiation in response to stress;process
hsa04140: Autophagy - animal