Table 6 Sensitivity and specificity of different LDL-C calculation methods
Direct LDL | Sensitivity | Specificity | Youden index | p-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
110> | 110< | |||||||||
N | Percentage | N | Percentage | |||||||
Total | Ahmadi LDL | Low | 2539 | 80.7 | 230 | 33 | 67 | 80.7 | 47.7 | < 0.001 |
High | 609 | 19.3 | 466 | 67 | ||||||
Friedwald LDL | Low | 3087 | 98.1 | 83 | 11.9 | 88.1 | 98.1 | 86.2 | < 0.001 | |
High | 61 | 1.9 | 613 | 88.1 | ||||||
Anandraja LDL | Low | 2850 | 90.5 | 73 | 10.5 | 89.5 | 90.5 | 80 | < 0.001 | |
High | 298 | 9.5 | 623 | 89.5 | ||||||
Chen LDL | Low | 3108 | 98.7 | 187 | 26.9 | 73.1 | 98.7 | 71.8 | < 0.001 | |
High | 40 | 1.3 | 509 | 73.1 | ||||||
New formula | Low | 3113 | 98.9 | 102 | 14.7 | 85.3 | 98.9 | 84.2 | < 0.001 | |
High | 35 | 1.1 | 594 | 85.3 | ||||||
TG < 100 | Ahmadi LDL | Low | 2269 | 98.1 | 230 | 49.5 | 50.5 | 98.1 | 48.6 | < 0.001 |
High | 45 | 1.9 | 235 | 50.5 | ||||||
Friedwald LDL | Low | 2273 | 98.2 | 54 | 11.6 | 88.4 | 98.2 | 86.6 | < 0.001 | |
High | 41 | 1.8 | 411 | 88.4 | ||||||
Anandraja LDL | Low | 2076 | 89.7 | 44 | 9.5 | 90.5 | 89.7 | 80.2 | < 0.001 | |
High | 238 | 10.3 | 421 | 90.5 | ||||||
Chen LDL | Low | 2310 | 99.8 | 155 | 33.3 | 66.7 | 99.8 | 66.5 | < 0.001 | |
High | 4 | 0.2 | 310 | 66.7 | ||||||
New formula | Low | 2291 | 99 | 66 | 14.2 | 85.8 | 99 | 84.8 | < 0.001 | |
High | 23 | 1 | 399 | 85.8 | ||||||
TG > 100 | Ahmadi LDL | Low | 270 | 32.4 | 0 | 0 | 100 | 32.4 | 32.4 | < 0.001 |
High | 564 | 67.6 | 231 | 100 | ||||||
Friedwald LDL | Low | 814 | 97.6 | 29 | 12.6 | 87.4 | 97.6 | 85 | < 0.001 | |
High | 20 | 2.4 | 202 | 87.4 | ||||||
Anandraja LDL | Low | 774 | 92.8 | 29 | 12.6 | 87.4 | 92.8 | 80.2 | < 0.001 | |
High | 60 | 7.2 | 202 | 87.4 | ||||||
Chen LDL | Low | 798 | 95.7 | 32 | 13.9 | 86.1 | 95.7 | 81.8 | < 0.001 | |
High | 36 | 4.3 | 199 | 86.1 | ||||||
New formula | Low | 822 | 98.6 | 36 | 15.6 | 84.4 | 98.6 | 83 | < 0.001 | |
High | 12 | 1.4 | 195 | 84.4 | ||||||