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Table 1 Main characteristics of the included studies

From: ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis

Study Year Region Ethnicity Genotyping method Sample size (case/control) Quality score HWE
Y/N 		ApoE ε2 (n) ApoE ε3 (n) ApoE ε4 (n)  
case control case control case control  
Horita et al. [17] 1994 Japan Asian Flat gel isoelectric focusing 57/ 398 7 Y 11 25 87 669 16 102  
Eto et al. [18] 1995 Japan Asian Flat gel isoelectric focusing 146/ 135 5 Y 21 7 235 229 36 34  
Kimura et al. [19] 1998 Japan Asian PCR 81/ 96 7 Y 7 10 143 154 12 28  
Zhang et al. [20] 1999 China Asian PCR 57/ 40 6 Y 34 11 62 53 18 16  
Xiang et al. [21] 1999 China Asian PCR 46/ 84 8 Y 12 9 71 137 9 22  
Ha et al. [22] 1999 Korea Asian PCR 74/ 93 7 Y 18 8 119 163 11 15  
Akarsu et al. [23] 2000 Turkey Turkish PCR 24/ 22 7 Y 11 3 33 35 4 6  
Dai et al. [24] 2000 China Asian PCR 88/ 32 5 Y 14 5 143 54 19 5  
Shen et al. [25] 2002 China Asian PCR 159/ 106 5 Y 38 11 250 186 30 15  
Zhang et al. [26] 2002 China Asian PCR 58/ 56 7 Y 17 4 86 94 13 14  
Liu et al. [27] 2003 China Asian PCR 218/ 80 7 Y 40 12 351 135 45 13  
Park et al. [28] 2004 Korea Asian PCR 48/ 70 6 Y 12 3 79 123 5 14  
Liu et al. [29] 2004 China Asian PCR 56/ 28 5 Y 15 2 87 49 10 5  
Xiong et al. [30] 2005 China Asian PCR 33/ 32 6 Y 7 8 51 51 8 5  
Hua et al. [31] 2006 China Asian FRET-RELP 52/ 50 7 N 23 12 160 160 17 28  
Guo et al. [32] 2006 China Asian PCR 32/ 25 5 N 18 4 42 42 4 4  
Ng et al. [33] 2006 China Asian PCR 366/ 386 8 Y 83 66 594 656 55 50  
Zhang et al. [34] 2007 China Asian PCR 40/ 38 6 Y 9 2 61 69 10 5  
Pan et al. [35] 2007 China Asian PCR 113/ 97 7 Y 17 20 172 163 37 11  
Ilhan et al. [36] 2007 Turkey Turkish PCR 37/ 71 7 N 3 14 63 118 8 10  
Kwon et al. [37] 2007 Korea Asian PCR 36/ 58 5 Y 7 9 61 92 4 15  
Leiva et al. [38] 2007 Chile Latin PCR 56/ 29 7 Y 1 1 102 42 9 15  
Rouzi et al. [39] 2008 China Asian PCR 36/ 17 6 N 16 4 52 26 4 4  
Erdogan et al. [40] 2009 Turkey Turkish PCR 46/ 56 7 Y 5 4 80 96 7 12  
Xiang et al. [41] 2010 China Asian PCR 177/ 41 5 Y 57 6 279 68 18 8  
Reis et al. [42] 2011 Turkey Turkish PCR 106/ 110 7 Y 7 25 194 176 11 19  
Sun et al. [43] 2013 China Asian PCR 228/ 243 7 Y 54 48 357 417 45 21  
Satirapoj et al. [44] 2013 Thailand SE Asian PCR 115/ 115 6 Y 24 17 196 188 10 25  
Wang et al. [45] 2014 China Asian PCR 63/ 57 8 Y 28 6 79 83 19 25  
Luo et al. [46] 2016 China Asian PCR 45/ 35 5 Y 18 4 36 61 36 5  
Atta et al. [47] 2016 Egypt Arabian PCR 45/ 45 7 N 45 24 27 45 18 21  
Jiang et al. [48] 2017 China Asian Genotyping chip 429/ 416 8 N 74 33 708 699 76 100  
Karimoei et al. [49] 2017 Iran Persian PCR 99/ 98 8 Y 14 10 163 146 21 40  
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Lipids in Health and Disease

ISSN: 1476-511X