Table 1 Main characteristics of the included studies
Study | Year | Region | Ethnicity | Genotyping method | Sample size (case/control) | Quality score | HWE Y/N | ApoE ε2 (n) | ApoE ε3 (n) | ApoE ε4 (n) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
case | control | case | control | case | control | ||||||||||
Horita et al. [17] | 1994 | Japan | Asian | Flat gel isoelectric focusing | 57/ | 398 | 7 | Y | 11 | 25 | 87 | 669 | 16 | 102 | |
Eto et al. [18] | 1995 | Japan | Asian | Flat gel isoelectric focusing | 146/ | 135 | 5 | Y | 21 | 7 | 235 | 229 | 36 | 34 | |
Kimura et al. [19] | 1998 | Japan | Asian | PCR | 81/ | 96 | 7 | Y | 7 | 10 | 143 | 154 | 12 | 28 | |
Zhang et al. [20] | 1999 | China | Asian | PCR | 57/ | 40 | 6 | Y | 34 | 11 | 62 | 53 | 18 | 16 | |
Xiang et al. [21] | 1999 | China | Asian | PCR | 46/ | 84 | 8 | Y | 12 | 9 | 71 | 137 | 9 | 22 | |
Ha et al. [22] | 1999 | Korea | Asian | PCR | 74/ | 93 | 7 | Y | 18 | 8 | 119 | 163 | 11 | 15 | |
Akarsu et al. [23] | 2000 | Turkey | Turkish | PCR | 24/ | 22 | 7 | Y | 11 | 3 | 33 | 35 | 4 | 6 | |
Dai et al. [24] | 2000 | China | Asian | PCR | 88/ | 32 | 5 | Y | 14 | 5 | 143 | 54 | 19 | 5 | |
Shen et al. [25] | 2002 | China | Asian | PCR | 159/ | 106 | 5 | Y | 38 | 11 | 250 | 186 | 30 | 15 | |
Zhang et al. [26] | 2002 | China | Asian | PCR | 58/ | 56 | 7 | Y | 17 | 4 | 86 | 94 | 13 | 14 | |
Liu et al. [27] | 2003 | China | Asian | PCR | 218/ | 80 | 7 | Y | 40 | 12 | 351 | 135 | 45 | 13 | |
Park et al. [28] | 2004 | Korea | Asian | PCR | 48/ | 70 | 6 | Y | 12 | 3 | 79 | 123 | 5 | 14 | |
Liu et al. [29] | 2004 | China | Asian | PCR | 56/ | 28 | 5 | Y | 15 | 2 | 87 | 49 | 10 | 5 | |
Xiong et al. [30] | 2005 | China | Asian | PCR | 33/ | 32 | 6 | Y | 7 | 8 | 51 | 51 | 8 | 5 | |
Hua et al. [31] | 2006 | China | Asian | FRET-RELP | 52/ | 50 | 7 | N | 23 | 12 | 160 | 160 | 17 | 28 | |
Guo et al. [32] | 2006 | China | Asian | PCR | 32/ | 25 | 5 | N | 18 | 4 | 42 | 42 | 4 | 4 | |
Ng et al. [33] | 2006 | China | Asian | PCR | 366/ | 386 | 8 | Y | 83 | 66 | 594 | 656 | 55 | 50 | |
Zhang et al. [34] | 2007 | China | Asian | PCR | 40/ | 38 | 6 | Y | 9 | 2 | 61 | 69 | 10 | 5 | |
Pan et al. [35] | 2007 | China | Asian | PCR | 113/ | 97 | 7 | Y | 17 | 20 | 172 | 163 | 37 | 11 | |
Ilhan et al. [36] | 2007 | Turkey | Turkish | PCR | 37/ | 71 | 7 | N | 3 | 14 | 63 | 118 | 8 | 10 | |
Kwon et al. [37] | 2007 | Korea | Asian | PCR | 36/ | 58 | 5 | Y | 7 | 9 | 61 | 92 | 4 | 15 | |
Leiva et al. [38] | 2007 | Chile | Latin | PCR | 56/ | 29 | 7 | Y | 1 | 1 | 102 | 42 | 9 | 15 | |
Rouzi et al. [39] | 2008 | China | Asian | PCR | 36/ | 17 | 6 | N | 16 | 4 | 52 | 26 | 4 | 4 | |
Erdogan et al. [40] | 2009 | Turkey | Turkish | PCR | 46/ | 56 | 7 | Y | 5 | 4 | 80 | 96 | 7 | 12 | |
Xiang et al. [41] | 2010 | China | Asian | PCR | 177/ | 41 | 5 | Y | 57 | 6 | 279 | 68 | 18 | 8 | |
Reis et al. [42] | 2011 | Turkey | Turkish | PCR | 106/ | 110 | 7 | Y | 7 | 25 | 194 | 176 | 11 | 19 | |
Sun et al. [43] | 2013 | China | Asian | PCR | 228/ | 243 | 7 | Y | 54 | 48 | 357 | 417 | 45 | 21 | |
Satirapoj et al. [44] | 2013 | Thailand | SE Asian | PCR | 115/ | 115 | 6 | Y | 24 | 17 | 196 | 188 | 10 | 25 | |
Wang et al. [45] | 2014 | China | Asian | PCR | 63/ | 57 | 8 | Y | 28 | 6 | 79 | 83 | 19 | 25 | |
Luo et al. [46] | 2016 | China | Asian | PCR | 45/ | 35 | 5 | Y | 18 | 4 | 36 | 61 | 36 | 5 | |
Atta et al. [47] | 2016 | Egypt | Arabian | PCR | 45/ | 45 | 7 | N | 45 | 24 | 27 | 45 | 18 | 21 | |
Jiang et al. [48] | 2017 | China | Asian | Genotyping chip | 429/ | 416 | 8 | N | 74 | 33 | 708 | 699 | 76 | 100 | |
Karimoei et al. [49] | 2017 | Iran | Persian | PCR | 99/ | 98 | 8 | Y | 14 | 10 | 163 | 146 | 21 | 40 | |