Table 1 Baseline characteristics of study participants
|  | LDL-C < 1.8 mmol/L | LDL-C ≥ 1.8 mmol/L | P value |
|---|---|---|---|
N | 320 | 320 | – |
Male: Female | 232:88 | 217:103 | 0.195 |
Age (Y) | 65.2 ± 11.3 | 65.5 ± 11.1 | 0.748 |
Smoking (%) | 143 (44.7) | 150 (46.9) | 0.579 |
Drinking (%) | 40 (12.5) | 44 (13.8) | 0.640 |
SBP (mmHg) | 139.4 ± 21.2 | 142.4 ± 23.8 | 0.098 |
DBP (mmHg) | 77.4 ± 13.1 | 78.5 ± 13.0 | 0.278 |
BMI (kg/m2) | 24.5 ± 4.2 | 24.8 ± 4.3 | 0.394 |
Medical condition | |||
 EH (%) | 214 (66.9) | 236 (73.8) | 0.057 |
 CAD (%) | 266 (83.1) | 255 (79.7) | 0.264 |
 T2D (%) | 174 (54.4) | 174 (54.4) | 1.000 |
 AF (%) | 10 (3.1) | 17 (5.3) | 0.169 |
Blood biochemical index | |||
 TRIG (mmol/L) | 1.46 ± 1.01 | 1.70 ± 1.00 | 0.003 |
 TC (mmol/L) | 3.27 ± 0.70 | 4.70 ± 1.12 | < 0.001 |
 HDL-C (mmol/L) | 1.07 ± 0.29 | 1.08 ± 0.23 | 0.507 |
 Apo B (mg/dL) | 64.9 ± 21.4 | 100.4 ± 33.0 | < 0.001 |
 Apo A1 (mg/dL) | 102.4 ± 23.7 | 103.4 ± 23.3 | 0.560 |
 WBC (×109/L) | 8.31 ± 2.90 | 8.32 ± 2.61 | 0.962 |
 HGB (g/L) | 132.3 ± 18.8 | 129.8 ± 17.2 | 0.076 |
 PLT (×109/L) | 228.6 ± 64.0 | 237.4 ± 66.3 | 0.088 |
 FBG (mmol/L) | 5.48 ± 1.20 | 5.62 ± 1.48 | 0.173 |
 P2hBS (mmol/L) | 9.01 ± 2.71 | 8.96 ± 2.66 | 0.825 |
 HbA1C (%) | 6.0 ± 1.1 | 6.0 ± 1.3 | 0.926 |
 Scr (μmol/L) | 92.0 ± 46.9 | 89.7 ± 34.0 | 0.468 |
 BUN (mmol/L) | 5.72 ± 2.09 | 5.81 ± 1.97 | 0.569 |
 UA (μmol/L) | 402.1 ± 107.8 | 397.4 ± 104.6 | 0.573 |
 ALT (U/L) | 25.7 ± 24.3 | 27.3 ± 34.4 | 0.483 |
 AST (U/L) | 47.9 ± 112.8 | 52.3 ± 105.4 | 0.612 |
 Alb (g/L) | 37.2 ± 3.5 | 36.7 ± 4.9 | 0.104 |
 Na+ (mmol/L) | 140.3 ± 3.4 | 140.2 ± 3.2 | 0.613 |
 K+ (mmol/L) | 3.76 ± 0.38 | 3.74 ± 0.43 | 0.416 |
 HsCRP (mg/L) | 10.9 ± 11.1 | 14.2 ± 19.1 | 0.009 |
 MAU (ACR, mg/g) | 229.0 ± 392.2 | 355.1 ± 480.2 | < 0.001 |
 HCY (μmol/L) | 14.7 ± 5.7 | 14.2 ± 5.9 | 0.342 |
 ACE (U/L) | 35.1 ± 23.2 | 33.6 ± 20.1 | 0.380 |
 Renin (pg/mL) | 27.1 ± 28.5 | 25.5 ± 27.2 | 0.479 |
 Ang I (ng/L) | 2.40 ± 1.79 | 2.51 ± 1.38 | 0.427 |
 Ang II (ng/L) | 64.4 ± 85.0 | 58.0 ± 78.9 | 0.325 |
 ALD (ng/L) | 171.0 ± 120.1 | 170.2 ± 88.3 | 0.928 |
Echocardiography | |||
RVD (cm) | 1.73 ± 0.19 | 1.75 ± 0.17 | 0.296 |
RAD (cm) | 3.36 ± 0.30 | 3.31 ± 0.30 | 0.064 |
LVD (cm) | 4.83 ± 0.58 | 4.76 ± 0.54 | 0.095 |
LAD (cm) | 3.11 ± 0.56 | 3.07 ± 0.57 | 0.336 |
LVEF (%) | 55.9 ± 10.8 | 56.7 ± 8.5 | 0.276 |