Lipids in Health and Disease

Table 2 Association between KATP SNPs and elevated LDL-C (≥1.8 mmol/L) in study participants

From: ATP-sensitive potassium channels gene polymorphism rs1799858 affects the risk of macro-/micro-vascular arteriosclerotic event in patients with increased low-density lipoprotein cholesterol levels

*KATP* SNPs		LDL-C ≥ 1.8 mmol/L (N/%)		Crude OR (95% CI)	Crude P value	Adjusted OR (95% CI)^a	Adjusted P value^a	Adjusted OR (95% CI)^b	Adjusted P value^b
*KATP* SNPs		NO	YES	Crude OR (95% CI)	Crude P value	Adjusted OR (95% CI)^a	Adjusted P value^a	Adjusted OR (95% CI)^b	Adjusted P value^b
rs1799858	CC	218 (68.1)	202 (63.1)	1.00		1.00		1.00
	TT + CT	102 (31.9)	118 (36.9)	1.25 (0.90–1.73)	0.183	1.50 (1.04–2.16)	0.032	2.25 (1.31–3.85)	0.003
rs4148671	CC	276 (86.3)	288 (90.0)	1.00		1.00		1.00
	TT + CT	44 (13.8)	32 (10.0)	0.70 (0.43–1.13)	0.144	0.72 (0.42–1.23)	0.224	0.61 (0.35–1.06)	0.078
rs78148713	CC + CT	20 (6.3)	12 (3.8)	0.58 (0.28–1.22)	0.151	0.51 (0.24–1.11)	0.091	0.96 (0.34–2.72)	0.935
	TT	300 (93.7)	308 (96.2)	1.00		1.00		1.00

^aModel 1: After adjustment for gender, age, smoking, drinking, WBC, BMI, EH, T2D, liver function (ALT, AST and Alb), renal function (Scr, BUN and UA), HsCRP, HbA1C, HCY, and RAAS activity (ACE, renin, Ang I, Ang II and ALD)
^bModel 2: It is the same as Model 1, and also including dyslipidemia (TRIG, TC, Apo B, HDL-C and Apo AI)

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