Lipids in Health and Disease

Table 2 Association^* of lipoprotein and insulin resistance score components with lipid species factors in the Lipid Lowering Drugs and Diet Network Study (n = 980)

From: A lipidome-wide association study of the lipoprotein insulin resistance index

	Storage lipids (Factor 1)			Non-storage lipids (Factor 2)			Mixed lipids (Factor 3)
Scores	β	SE	P-value^†	β	SE	P-value^†	β	SE	P-value^†
LPIR	0.025	0.001	4.52E-71	−0.013	0.001	2.78E-18	0.021	0.002	5.84E-41
VLDL_Size	−0.004	0.004	0.356	−0.013	0.004	0.002	0.046	0.004	6.06E-27
Large_VLDL	0.056	0.003	1.52E-65	−0.0161	0.003	4.11E-06	0.069	0.003	1.67E-96
LDL_Size	0.150	0.011	4.90E-43	−0.068	0.011	1.10E-09	0.008	0.013	0.533
Small_LDL	0.215	0.016	2.77E-40	−0.028	0.017	0.096	0.033	0.018	0.096
HDL_Size	0.066	0.005	3.62E-45	−0.036	0.005	6.36E-14	0.008	0.005	0.138
Large_HDL	0.113	0.007	2.87E-54	−0.079	0.007	1.05E-27	0.018	0.009	0.037
HOMA-IR	0.080	0.014	1.44E-08	−0.070	0.013	1.04E-07	0.107	0.015	6.30E-13

*Adjusted for age, sex, BMI, center and family relationship
†P-values were FDR corrected to account for multiple comparisons. Bolded values indicate statistical significance (at P-values < 0.05)
Abbreviations: SE Standard error, LPIR Lipoprotein insulin resistance, VLDL Very low-density lipoprotein, LDL Dense low-density lipoprotein, HDL High-density lipoprotein, HOMA-IR Homeostatic model assessment-insulin resistance

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ISSN: 1476-511X

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