| No. of participants/cases | Model 1a (HR (95%CI)) | Model 2b (HR (95%%CI)) | Model 3c (HR (95%%CI)) |
---|---|---|---|---|
Total | ||||
 Concordantly low LDL-C/HDL-C ratio, low LDL-C and normal HDL-C | 8158/977 | 1 | 1 | 1 |
 Discordantly low LDL-C/HDL-C ratio, high LDL-C and normal HDL-C | 1343/246 | 1.21 (1.05, 1.39) | 1.33 (1.12, 1.59) | 1.32 (1.11, 1.57) |
 Discordantly low LDL/HDL-C ratio, low LDL-C and abnormal HDL-C | 679/84 | 1.08 (0.86, 1.35) | 1.01 (0.8, 1.27) | 0.99 (0.79, 1.25) |
 Discordantly high LDL/HDL-C ratio, low LDL-C and normal HDL-C | 472/77 | 1.46 (1.15, 1.84) | 1.43 (1.13, 1.81) | 1.43 (1.13, 1.81) |
 Discordantly high LDL/HDL-C ratio, low LDL-C and abnormal HDL-C | 749/137 | 1.54 (1.29, 1.85) | 1.49 (1.23, 1.8) | 1.48 (1.22, 1.79) |
 Discordantly high LDL/HDL-C ratio, high LDL-C and normal HDL-C | 1793/401 | 1.74 (1.55, 1.96) | 1.84 (1.58, 2.13) | 1.82 (1.56, 2.11) |
 Concordantly high LDL/HDL-C ratio, high LDL-C and abnormal HDL-C | 418/74 | 2.08 (1.63, 2.64) | 1.97 (1.52, 2.54) | 1.87 (1.44, 2.42) |
Sensitivity analysis by excluding CIMT in the first 2 years | ||||
 Concordantly low LDL-C/HDL-C ratio, low LDL-C and normal HDL-C | 8158/789 | 1 | 1 | 1 |
 Discordantly low LDL-C/HDL-C ratio, high LDL-C and normal HDL-C | 1343/204 | 1.21 (1.03, 1.41) | 1.21 (1.04, 1.42) | 1.22 (1.04, 1.43) |
 Discordantly low LDL/HDL-C ratio, low LDL-C and abnormal HDL-C | 679/62 | 1.01 (0.78, 1.31) | 0.95 (0.73, 1.24) | 0.92 (0.70, 1.21) |
 Discordantly high LDL/HDL-C ratio, low LDL-C and normal HDL-C | 472/61 | 1.45 (1.12, 1.89) | 1.44 (1.1, 1.87) | 1.42 (1.09, 1.85) |
 Discordantly high LDL/HDL-C ratio, low LDL-C and abnormal HDL-C | 749/105 | 1.49 (1.21, 1.83) | 1.41 (1.14, 1.75) | 1.39 (1.12, 1.73) |
 Discordantly high LDL/HDL-C ratio, high LDL-C and normal HDL-C | 1793/319 | 1.72 (1.51, 1.97) | 1.69 (1.47, 1.94) | 1.69 (1.47, 1.94) |
 Concordantly high LDL/HDL-C ratio, high LDL-C and abnormal HDL-C | 418/53 | 2.01 (1.51, 2.66) | 1.83 (1.36, 2.46) | 1.75 (1.30, 2.35) |
Sensitivity analysis by excluding T2DM at baseline | ||||
 Concordantly low LDL-C/HDL-C ratio, low LDL-C and normal HDL-C | 7882/910 | 1 | 1 | 1 |
 Discordantly low LDL-C/HDL-C ratio, high LDL-C and normal HDL-C | 1287/238 | 1.23 (1.07, 1.42) | 1.22 (1.05, 1.41) | 1.22 (1.06, 1.42) |
 Discordantly low LDL/HDL-C ratio, low LDL-C and abnormal HDL-C | 616/72 | 1.06 (0.83, 1.35) | 1.04 (0.81, 1.33) | 1.02 (0.79, 1.31) |
 Discordantly high LDL/HDL-C ratio, low LDL-C and normal HDL-C | 441/71 | 1.49 (1.17, 1.9) | 1.50 (1.17, 1.91) | 1.50 (1.17, 1.91) |
 Discordantly high LDL/HDL-C ratio, low LDL-C and abnormal HDL-C | 696/120 | 1.50 (1.23, 1.82) | 1.45 (1.19, 1.78) | 1.45 (1.18, 1.77) |
 Discordantly high LDL/HDL-C ratio, high LDL-C and normal HDL-C | 1662/369 | 1.77 (1.56, 2.00) | 1.74 (1.53, 1.97) | 1.73 (1.52, 1.96) |
 Concordantly high LDL/HDL-C ratio, high LDL-C and abnormal HDL-C | 379/61 | 1.93 (1.49, 2.51) | 1.85 (1.41, 2.43) | 1.80 (1.37, 2.37) |