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Table 4 Association between LDL-C/HDL-C ratio concordance with LDL-C, HDL-C and CIMT risk

From: LDL-cholesterol to HDL-cholesterol ratio discordance with lipid parameters and carotid intima-media thickness: a cohort study in China

 

No. of participants/cases

Model 1a

(HR (95%CI))

Model 2b

(HR (95%%CI))

Model 3c

(HR (95%%CI))

Total

 Concordantly low LDL-C/HDL-C ratio, low LDL-C and normal HDL-C

8158/977

1

1

1

 Discordantly low LDL-C/HDL-C ratio, high LDL-C and normal HDL-C

1343/246

1.21 (1.05, 1.39)

1.33 (1.12, 1.59)

1.32 (1.11, 1.57)

 Discordantly low LDL/HDL-C ratio, low LDL-C and abnormal HDL-C

679/84

1.08 (0.86, 1.35)

1.01 (0.8, 1.27)

0.99 (0.79, 1.25)

 Discordantly high LDL/HDL-C ratio, low LDL-C and normal HDL-C

472/77

1.46 (1.15, 1.84)

1.43 (1.13, 1.81)

1.43 (1.13, 1.81)

 Discordantly high LDL/HDL-C ratio, low LDL-C and abnormal HDL-C

749/137

1.54 (1.29, 1.85)

1.49 (1.23, 1.8)

1.48 (1.22, 1.79)

 Discordantly high LDL/HDL-C ratio, high LDL-C and normal HDL-C

1793/401

1.74 (1.55, 1.96)

1.84 (1.58, 2.13)

1.82 (1.56, 2.11)

 Concordantly high LDL/HDL-C ratio, high LDL-C and abnormal HDL-C

418/74

2.08 (1.63, 2.64)

1.97 (1.52, 2.54)

1.87 (1.44, 2.42)

Sensitivity analysis by excluding CIMT in the first 2 years

 Concordantly low LDL-C/HDL-C ratio, low LDL-C and normal HDL-C

8158/789

1

1

1

 Discordantly low LDL-C/HDL-C ratio, high LDL-C and normal HDL-C

1343/204

1.21 (1.03, 1.41)

1.21 (1.04, 1.42)

1.22 (1.04, 1.43)

 Discordantly low LDL/HDL-C ratio, low LDL-C and abnormal HDL-C

679/62

1.01 (0.78, 1.31)

0.95 (0.73, 1.24)

0.92 (0.70, 1.21)

 Discordantly high LDL/HDL-C ratio, low LDL-C and normal HDL-C

472/61

1.45 (1.12, 1.89)

1.44 (1.1, 1.87)

1.42 (1.09, 1.85)

 Discordantly high LDL/HDL-C ratio, low LDL-C and abnormal HDL-C

749/105

1.49 (1.21, 1.83)

1.41 (1.14, 1.75)

1.39 (1.12, 1.73)

 Discordantly high LDL/HDL-C ratio, high LDL-C and normal HDL-C

1793/319

1.72 (1.51, 1.97)

1.69 (1.47, 1.94)

1.69 (1.47, 1.94)

 Concordantly high LDL/HDL-C ratio, high LDL-C and abnormal HDL-C

418/53

2.01 (1.51, 2.66)

1.83 (1.36, 2.46)

1.75 (1.30, 2.35)

Sensitivity analysis by excluding T2DM at baseline

 Concordantly low LDL-C/HDL-C ratio, low LDL-C and normal HDL-C

7882/910

1

1

1

 Discordantly low LDL-C/HDL-C ratio, high LDL-C and normal HDL-C

1287/238

1.23 (1.07, 1.42)

1.22 (1.05, 1.41)

1.22 (1.06, 1.42)

 Discordantly low LDL/HDL-C ratio, low LDL-C and abnormal HDL-C

616/72

1.06 (0.83, 1.35)

1.04 (0.81, 1.33)

1.02 (0.79, 1.31)

 Discordantly high LDL/HDL-C ratio, low LDL-C and normal HDL-C

441/71

1.49 (1.17, 1.9)

1.50 (1.17, 1.91)

1.50 (1.17, 1.91)

 Discordantly high LDL/HDL-C ratio, low LDL-C and abnormal HDL-C

696/120

1.50 (1.23, 1.82)

1.45 (1.19, 1.78)

1.45 (1.18, 1.77)

 Discordantly high LDL/HDL-C ratio, high LDL-C and normal HDL-C

1662/369

1.77 (1.56, 2.00)

1.74 (1.53, 1.97)

1.73 (1.52, 1.96)

 Concordantly high LDL/HDL-C ratio, high LDL-C and abnormal HDL-C

379/61

1.93 (1.49, 2.51)

1.85 (1.41, 2.43)

1.80 (1.37, 2.37)

  1. aModel 1: adjusted for age, gender at baseline
  2. bModel 2: adjusted for age, gender, BMI, smoking, drinking, WC, TC, TG, creatinine, lipid-lowering medications, T2DM, hypertension, and fatty liver at baseline
  3. cModel 3: adjusted for age, gender, BMI, smoking, drinking, WC, TC, TG, creatinine, WBC, lipid-lowering medications, T2DM, hypertension, and fatty liver at baseline