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Table 1 Clinical characteristics of the patients

From: “Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia

Feature Adults with FH Healthy adults P Children with FH Healthy children P
Age [years (SD)] 37.5 (7.4) 38.6 (6.4) 0.5772 11.1 (4.5) 9.8 (4.0) 0.3148
Sex
 Females [n (%)] 10 10 1.000 16 15 0.7924
 Males [n (%)] 10 10   13 14  
BMI [kg/m2 (SD)] 24.2 (1.9) 23.9 (1.8) 0.5778 18.5 (3.2) 17.2 (2.1) 0.1087
Smoking (pack years) [years] 6.26 (2.8) 6.28 (4.0) 0.9929 0 0 1.000
Hypertension [n (%)] 7 (35) 6 (30) 0.7924 0 0 1.000
HbA1C 4.89 (0.38) 5.01 (0.15) 0.1523 3.99 (1.29) 4.23 (1.18) 0.8473
TC 316.55 (65.57) 158.52 (16.81) < 0.0001* 365.38 (99.23) 107.30 (18.09) < 0.0001*
LDL 217.50 (53.47) 80.70 (16.97) < 0.0001* 242.45 (58.33) 57.00 (12.15) < 0.0001*
HDL 68.91 (32.32) 58.17 (18.67) 0.1772 48.73 (14.82) 52.30 (8.35) 0.3128
Non-HDL 247.63 (79.82) 100.35 (21.07) < 0.0001 316.65 (98.05) 55.00 (18.70) < 0.0001
TG 111.63 (25.21) 93.04 (16.88) 0.0056* 99.35 (32.22) 59.78 (14.33) < 0.0001*
  1. HbA1C Glycosylated Hemoglobin, Type A1C, TC total cholesterol, LDL Low-density lipoprotein, HDL High-density lipoprotein, TG Triglycerides, P p-value
  2. *Significant differences according to Mann-Whitney test