Lipids in Health and Disease

Table. 2 Comparison of atherosclerosis surrogates between patients with FH and healthy control according to generations

From: “Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia

Feature	Adults with FH	Healthy adults	P	Children with FH	Healthy children	P	Adults with FH	Children with FH	P	Healthy adults	Healthy children	P
Atherosclerotic plaques [n (%)]	9	2	0.0231	0	0	1.000
Mean IMCT [mm (SD)]	0.84 (0.19)	0.56 (0.06)	< 0.0001	0.42 (0.07)	0.39 (0.04)	0.1722	0.84 (0.19)	0.42 (0.07)	< 0.0001	0.56 (0.06)	0.39 (0.04)	< 0.0001
PWV [m/s (SD)]	6.12 (1.08)	5.04 (1.38)	0.0055	4.50 (0.64)	3.96 (0.62)	0.0047	6.12 (1.08)	4.50 (0.64)	< 0.0001	5.04 (1.38)	3.96 (0.62)	0.0014
AI [% (SD)]	12.27 (5.01)	16.03 (5.24)	0.0179	18.30 (8.07)	24.43 (7.34)	0.0080	12.27 (5.01)	18.30 (8.07)	0.0039	16.03 (5.24)	24.43 (7.34)	0.0001
Strain [% (SD)]	6.25 (2.30)	8.15 (2.46)	0.0103	9.22 (3.40)	11.93 (3.11)	0.0057	6.25 (2.30)	9.22 (3.40)	0.0011	8.15 (2.46)	11.93 (3.11)	< 0.0001
Strain rate [1/s (SD)]	0.61 (0.27)	0.84 (0.29)	0.0081	0.93 (0.32)	1.25 (0.41)	0.0031	0.61 (0.27)	0.93 (0.32)	0.0006	0.84 (0.29)	1.25 (0.41)	0.0003

IMCT intima media complex thickness, PVW pulse wave velocity, AI augmentation index, P p-value

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