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Table. 2 Comparison of atherosclerosis surrogates between patients with FH and healthy control according to generations

From: “Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia

Feature Adults with FH Healthy adults P Children with FH Healthy children P Adults with FH Children with FH P Healthy adults Healthy children P
Atherosclerotic plaques [n (%)] 9 2 0.0231 0 0 1.000       
Mean IMCT
[mm (SD)]
0.84 (0.19) 0.56 (0.06) < 0.0001 0.42 (0.07) 0.39 (0.04) 0.1722 0.84 (0.19) 0.42 (0.07) < 0.0001 0.56 (0.06) 0.39 (0.04) < 0.0001
PWV [m/s (SD)] 6.12 (1.08) 5.04 (1.38) 0.0055 4.50 (0.64) 3.96 (0.62) 0.0047 6.12 (1.08) 4.50 (0.64) < 0.0001 5.04 (1.38) 3.96 (0.62) 0.0014
AI [% (SD)] 12.27 (5.01) 16.03 (5.24) 0.0179 18.30 (8.07) 24.43 (7.34) 0.0080 12.27 (5.01) 18.30 (8.07) 0.0039 16.03 (5.24) 24.43 (7.34) 0.0001
Strain [% (SD)] 6.25 (2.30) 8.15 (2.46) 0.0103 9.22 (3.40) 11.93 (3.11) 0.0057 6.25 (2.30) 9.22 (3.40) 0.0011 8.15 (2.46) 11.93 (3.11) < 0.0001
Strain rate
[1/s (SD)]
0.61 (0.27) 0.84 (0.29) 0.0081 0.93 (0.32) 1.25 (0.41) 0.0031 0.61 (0.27) 0.93 (0.32) 0.0006 0.84 (0.29) 1.25 (0.41) 0.0003
  1. IMCT intima media complex thickness, PVW pulse wave velocity, AI augmentation index, P p-value