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Table 3 Comparison of atherosclerosis surrogates between children with presumed pathogenic gene variants and those with presumed benign variants

From: “Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia

Feature Presumed pathogenic variants Presumed benign variants P
Mean IMCT [mm (SD)] 0.85 (0.22) 0.82 (0.16) 0.6548
PWV [m/s (SD)] 6.36 (1.10) 5.79 (1.01) 0.2304
AI [% (SD)] 11.98 (5.43) 12.69 (4.63) 0.7518
Strain [% (SD)] 5.63 (2.29) 7.13 (2.11) 0.1347
Strain rate [1/s (SD)] 0.58 (0.32) 0.64 (0.20) 0.6283
  1. IMCT intima media complex thickness, PVW pulse wave velocity, AI augmentation index, P p-value