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Table 3 Comparison of atherosclerosis surrogates between children with presumed pathogenic gene variants and those with presumed benign variants

From: “Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia

Feature

Presumed pathogenic variants

Presumed benign variants

P

Mean IMCT [mm (SD)]

0.85 (0.22)

0.82 (0.16)

0.6548

PWV [m/s (SD)]

6.36 (1.10)

5.79 (1.01)

0.2304

AI [% (SD)]

11.98 (5.43)

12.69 (4.63)

0.7518

Strain [% (SD)]

5.63 (2.29)

7.13 (2.11)

0.1347

Strain rate [1/s (SD)]

0.58 (0.32)

0.64 (0.20)

0.6283

  1. IMCT intima media complex thickness, PVW pulse wave velocity, AI augmentation index, P p-value
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Lipids in Health and Disease

ISSN: 1476-511X