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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms

Fig. 1

Causes of PUFA (DHA in particular) deficiency in schizophrenia. Cause may be due to high ω6/ω3 diet, low synthesis due to abnormal metabolic enzymes, or low absorption due to mutated fatty acid binding protein; and elevated phospholipase A2 activity which release PUFAs from cell membrane. Abbreviations: AA, arachidonic acid (20:4n-6); ALA, alpha-linolenic acid (18:3n-3); DHA, docosahexaenoic acid (22:6n-3); FABP-7, fatty acid binding protein; FAD1/FAD2, delta-5 and delta-6 fatty acid desaturases; GPCR, G-protein coupling receptor; LA, linoleic acid (18:2n-6); PL, phospholipids; PLA2, phospholipase A2

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