The cholesterol-lowering effect of unripe Rubus coreanus is associated with decreased oxidized LDL and apolipoprotein B levels in subjects with borderline-high cholesterol levels: a randomized controlled trial

Table 2 Lipid-related parameters of placebo and test group at baseline and 12-week follow up

	Placebo group (n = 38)				uRC group (n = 39)				P^a	P^b	P^c
	Baseline		Follow-up		Baseline		Follow-up		P^a	P^b	P^c
Total-cholesterol (mg/dL)	213.86	±1.79	208.81	±3.95	214.05	±1.50	192.82	±4.07	0.938	0.006
Change		−5.05	±3.84			−21.23	±4.36				0.007
Triglyceride (mg/dL)	111.45	±6.22	119.26	±7.70	116.05	±7.13	115.49	±8.13	0.629	0.737
Change		−7.82	±7.84			--0.56	±7.06				0.429
LDL-cholesterol (mg/dL)	135.60	±2.58	132.55	±4.26	133.41	±2.06	117.79	±4.34	0.508	0.018
Change		−3.05	±3.95			−15.61	±4.16				0.032
Non-HDL-cholesterol (mg/dL)	153.71	±3.13	147.03	±4.33	153.41	±2.63	133.28	±4.40	0.942	0.029
Change		−6.68	±3.30			−20.13	±4.14				0.013
Apolipoprotein B (mg/dL)	114.39	±2.75	120.60	±3.82	115.17	±2.83	111.69	±3.46	0.843	0.088
Change		6.21	±2.84			−3.48	±3.40				0.032
Oxidized LDL (U/L)	68.05	±3.02	66.09	±3.47	64.31	±2.53	57.76	±2.07	0.348	0.044
Change		−1.95	±2.41			−6.23	±1.96				0.174

Mean ± SE (Standard Error), P^a-values derived from independent t-test at baseline baseline between the placebo and the uRC group. P^b-values derived from independent t-test at 12-week follow up between the placebo and the uRC group. P^c-values derived from independent t-test for changed value between the placebo and the uRC group. Change value (Δ, delta) represents the change from baseline at follow-up

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