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Table 4 Evolution of histopathological changes in the aorta and liver

From: Improvement in serum lipids and liver morphology after supplementation of the diet with fish oil is more evident under regular feeding conditions than under high-fat or mixed diets in rats

Treatment 14 days 28 days 42 days
Aorta Liver Aorta Liver Aorta Liver
SD 7–8 layers, smooth muscle/collagen Normal 8 layers Normal 7–8 layers Normal
n3 7–8 layers, smooth muscle/collagen Normal 7–8 layers Normal 6–8 layers Normal
HFD 7–8 layers, smooth muscle/collagen Normal 12–13 layers, vacuolated smooth muscle fibers Focal fatty change (periphery of central vein) 10–12 layers, hypertrophied and vacuolated smooth muscle fibers Micro- and macrovesicular fatty change
HFD + n3 7–8 layers, smooth muscle/collagen Normal 8–11 layers, hypertrophied and vacuolated smooth muscle fibers Hydropic change 8–10 layers, hypertrophied smooth muscle fibers Microvesicular fatty change
CA1 7–8 layers, smooth muscle/collagen Normal 8–12 layers, hypertrophied and vacuolated smooth muscle fibers Hydropic change 8–10 layers hypertrophied smooth muscle fibers Normal
CA2 7–8 layers, smooth muscle/collagen Normal 12 layers, hypertrophied and vacuolated smooth muscle fibers Focal fatty change (periphery of central vein) 8–11 layers, hypertrophied and vacuolated smooth muscle fibers Microvesicular fatty change