Improvement in serum lipids and liver morphology after supplementation of the diet with fish oil is more evident under regular feeding conditions than under high-fat or mixed diets in rats

Table 4 Evolution of histopathological changes in the aorta and liver

Treatment	14 days		28 days		42 days
Treatment	Aorta	Liver	Aorta	Liver	Aorta	Liver
SD	7–8 layers, smooth muscle/collagen	Normal	8 layers	Normal	7–8 layers	Normal
n3	7–8 layers, smooth muscle/collagen	Normal	7–8 layers	Normal	6–8 layers	Normal
HFD	7–8 layers, smooth muscle/collagen	Normal	12–13 layers, vacuolated smooth muscle fibers	Focal fatty change (periphery of central vein)	10–12 layers, hypertrophied and vacuolated smooth muscle fibers	Micro- and macrovesicular fatty change
HFD + n3	7–8 layers, smooth muscle/collagen	Normal	8–11 layers, hypertrophied and vacuolated smooth muscle fibers	Hydropic change	8–10 layers, hypertrophied smooth muscle fibers	Microvesicular fatty change
CA1	7–8 layers, smooth muscle/collagen	Normal	8–12 layers, hypertrophied and vacuolated smooth muscle fibers	Hydropic change	8–10 layers hypertrophied smooth muscle fibers	Normal
CA2	7–8 layers, smooth muscle/collagen	Normal	12 layers, hypertrophied and vacuolated smooth muscle fibers	Focal fatty change (periphery of central vein)	8–11 layers, hypertrophied and vacuolated smooth muscle fibers	Microvesicular fatty change

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