Fig. 2

Identification of differential lipids and lipid metabolites between senile pruritus patients and healthy person controls. a Heat map of SSL. The color is proportional to the intensity of SSL changes; red color represents upregulation, and blue represents down-regulation. b Volcano plot of SSL. The red dot represents 1.2 fold (right) and 0.83 fold (left) of variation and p < 0.05. Total 81 lipids with significant change have been identified based on their difference between two groups. c The comparison of 16 main class of lipids between idiopathic senile pruritus and controls. Compared to controls, 15 main class of lipids increased and only TAG decreased in senile pruritus. Results showed that there were significantly increased levels of Cer-EOS, Cer-NS, DAG, DGCC, DGTS, PC, PE, Cer-NP, Cer-OS, FA phytosphingsines and decreased level of TAG, while there were no significant changes of the relative amount of Cer-NP, Cer-BDS and sphingosines. *** P 0.001, ** P < 0.01, * P < 0.05