Fig. 5

Niacin does not alter HDL-mediated cholesterol efflux or endothelial signaling. HDL function assays were performed on samples collected at baseline, on niacin (week 16), and washout (week 20). a Efflux of radiolabeled cholesterol from macrophage cells to apoB depleted serum. b Activation of endothelial cell signaling pathways eNOS and Akt was evaluated by measurement of phosphorylation after treatment with isolated HDL. Statistical comparisons were made using repeated measures one-way ANOVA with false discovery rate (FDR) correction for multiple comparisons. FDR adjusted probability value: * q < 0.05, n.s. or no indicator = not significant