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Table 1 Subject Inclusion/Exclusion Criteria

From: Effect of niacin monotherapy on high density lipoprotein composition and function

Inclusion Criteria

Males and females who are at least 18 years of age at time of enrollment, with fasting HDL-C below 60 mg/dL.

Subject understands the investigational nature of the study and provides written, informed consent.

Exclusion Criteria

Subjects taking any lipid modification therapy, including but not limited to statins, fibrates and bile acid sequestrants.

Subjects taking fish oil or any other supplements, which in the investigator’s opinion may interfere with the study.

Subjects with acute liver disease or active peptic ulcer disease.

Subjects with elevated uric acid levels or gout

Pregnancy or women currently breastfeeding.

Female subjects taking hormonal contraceptives or hormone replacement therapy may be included in this study only if they have been on a stable dose for at least 3 months.

BMI less than 18.5

Subjects with weight that varies greater than 20% over the past 3 months

BAS, antibiotics, anticoagulants, anticonvulsants, antiarrhythmic, Cyclosporine, Mycophenolate and Synthroid. Subjects with chronic diarrhea, gastric bypass or lap band procedures, ostomies, bowel motility problems, or other conditions that could affect intestinal fat absorption.

Subjects initiating new medications or patients on multiple medications may also be excluded.

Inability to swallow tablets

Patients with a history of type I or type II diabetes or HbA1c > 6.5%.

Volunteers may also be excluded, if in the opinion of the study investigators, they have some other condition or disorder that may adversely affect the outcome of the study or the safety of the volunteer.