A minor allele of the haplotype located in the 19q13 loci is associated with a decreased risk of hyper-LDL-cholesterolemia, and a balanced diet and high protein intake can reduce the risk

Table 2 The characteristics of the three genetic variants used for haplotype located in the 19q13 loci

SNP	Position	Mi	Ma	OR	P value for OR	MAF	HWE_P	Gene	Location
rs7259620	45,407,788	A	G	0.834	3.79E-19	0.284	0.737	APOE	near-gene-5
rs403155	45,363,299	T	C	0.789	3.30E-15	0.107	0.475	PVRL2	intron
rs157581	45,395,714	C	T	0.911	2.64E-19	0.236	0.250	TOMM40	coding-synonymous
rs10406604	45,723,986	A	G	0.917	8.58E-05	0.221	0.094	EXOC3L2	intron
rs3212986	45,912,736	A	C	0.926	1.64E-04	0.266	0.976	CD3EAP	missense

APOE Apolipoprotein E, PVRL2 Poliovirus receptor-related 2 (nectin-2 and CD112), TOMM40 Translocase of outer mitochondrial membrane 40 homolog, EXOC3L2 Exocyst complex component 3 Like 2, CD3EAP CD3e molecule associated protein, CHR Chromosome, SNP Single nucleotide polymorphism, Mi Minor allele, Ma Major allele, OR Odds ratios (OR) for serum LDL concentration in the reference of the major allele; P value for OR adjusted for age, gender, residence area, body mass index, and energy intake, MAF Minor allele frequency, HWE_P P value for Hardy-Weinberg equilibrium

ISSN: 1476-511X