Skip to main content

Table 4 The estimated logistic regression coefficients (β’s), adjusted odds ratios and 95% confidence intervals for the risk of lipid profiles according to the alleles of the haplotypea according to serum LDL cholesterol concentrations after covariate adjustments

From: A minor allele of the haplotype located in the 19q13 loci is associated with a decreased risk of hyper-LDL-cholesterolemia, and a balanced diet and high protein intake can reduce the risk

  Model 1 Model 2
Major
(n = 1782)
Heterozygote
(n = 1680)
Minor
(n = 301)
Heterozygote
(n = 1680)
Minor
(n = 301)
Total cholesterolb
(mg/dl)
1 0.084, 0.940
(0.893 ~ 0.988)
− 0.234***, 0.683
(0.629 ~ 0.742)
0.082, 0.928
(0.881 ~ 0.978)
−0.242***, 0.669
(0.614 ~ 0.730)
LDLc
(mg/dl)
1 0.098, 0.898
(0.853 ~ 0.946)
−0.249***, 0.675
(0.592 ~ 0.769)
0.089, 0.956
(0.842 ~ 0.975)
−0.237***, 0.684
(0.598 ~ 0.782)
HDLd
(mg/dl)
1 0.006, 0.969
(0.917 ~ 1.023)
−0.056, 0.908
(0.837 ~ 0.999)
0.031, 0.966
(0.912 ~ 1.023)
−0.110***, 0.845
(0.769 ~ 0.928)
Triglyceridee
(mg/dl)
1 −0.026, 1.088
(1.028 ~ 1.151)
0.125***, 1.243
(1.138 ~ 1.358)
−0.048, 1.110
(1.046 ~ 1.177)
0.188***, 1.387
(1.265 ~ 1.522)
Ratio of LD and HDLf 1 0.072**, 0.905
(0.854 ~ 0.959)
−0.244***, 0.667
(0.604 ~ 0.737)
0.041, 0.916
(0.876 ~ 1.000)
−0.160***, 0.770
(0.687 ~ 0.864)
Cardiovascular diseases 1 0.050, 1.018
(0.895–1.158)
−0.096, 0.858
(0.686–1.073)
0.076, 0.968
(0.846–1.108)
− 0.184*, 0.746
(0.592–0.941)
Myocardial infarction 1 0.067, 0.987
(0.783–1.245)
−0.121, 0.922
(0.624–1.363)
0.086, 0.965
(0.825–1.128)
−0.208*, 0.719
(0.549–0.943)
Stroke 1 0.002, 1.024
(0.882–1.189)
−0.033, 0.831
(0.639–1.082)
0.032, 0.961
(0.756–1.221)
− 0.105, 0.838
(0.559–1.256)
  1. Values represent odds ratios and 95% confidence intervals
  2. aHaplotypes of APOE, PVRL2, TOMM40, EXOC3L2, and CD3EAP in the 19q13 loci were generated by PLINK and it was divided into 3 categories (Major, Heterozygote and Minor haplotype groups) by the alleles (0, 1–2, and 3–4). The Major haplotype was the reference for both model 1 and model 2
  3. The cutoff points for dividing the values of each parameter into 2 groups were as follows: the control group included < 200 mg/dL for serum total cholesterol concentrationsb, < 160 mg/dL for serum LDL concentrations (LDL)c, ≥40 mg/dL for men and ≥ 50 mg/dL for women in serum HDL concentrations (HDL)d, < 150 mg/dL for serum triglyceride concentrationse and 2.85 for the ratio of serum LDL concentrations to serum HDL concentrationsf
  4. Model 1: adjusted for age, gender, residence area, body mass index, and energy intake
  5. Model 2: adjusted for the parameter in model 1 plus smoking, coffee, alcohol, physical activity, percent of fat and carbohydrate intakes, menopause, and serum total cholesterol concentrations
  6. * Significantly changed the risk of hyper-LDL-cholesterolemia by haplotype at P < 0.05, ** at P < 0.01, and *** at P < 0.0001