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Table 4 The estimated logistic regression coefficients (β’s), adjusted odds ratios and 95% confidence intervals for the risk of lipid profiles according to the alleles of the haplotypea according to serum LDL cholesterol concentrations after covariate adjustments

From: A minor allele of the haplotype located in the 19q13 loci is associated with a decreased risk of hyper-LDL-cholesterolemia, and a balanced diet and high protein intake can reduce the risk

 

Model 1

Model 2

Major

(n = 1782)

Heterozygote

(n = 1680)

Minor

(n = 301)

Heterozygote

(n = 1680)

Minor

(n = 301)

Total cholesterolb

(mg/dl)

1

0.084, 0.940

(0.893 ~ 0.988)

− 0.234***, 0.683

(0.629 ~ 0.742)

0.082, 0.928

(0.881 ~ 0.978)

−0.242***, 0.669

(0.614 ~ 0.730)

LDLc

(mg/dl)

1

0.098, 0.898

(0.853 ~ 0.946)

−0.249***, 0.675

(0.592 ~ 0.769)

0.089, 0.956

(0.842 ~ 0.975)

−0.237***, 0.684

(0.598 ~ 0.782)

HDLd

(mg/dl)

1

0.006, 0.969

(0.917 ~ 1.023)

−0.056, 0.908

(0.837 ~ 0.999)

0.031, 0.966

(0.912 ~ 1.023)

−0.110***, 0.845

(0.769 ~ 0.928)

Triglyceridee

(mg/dl)

1

−0.026, 1.088

(1.028 ~ 1.151)

0.125***, 1.243

(1.138 ~ 1.358)

−0.048, 1.110

(1.046 ~ 1.177)

0.188***, 1.387

(1.265 ~ 1.522)

Ratio of LD and HDLf

1

0.072**, 0.905

(0.854 ~ 0.959)

−0.244***, 0.667

(0.604 ~ 0.737)

0.041, 0.916

(0.876 ~ 1.000)

−0.160***, 0.770

(0.687 ~ 0.864)

Cardiovascular diseases

1

0.050, 1.018

(0.895–1.158)

−0.096, 0.858

(0.686–1.073)

0.076, 0.968

(0.846–1.108)

− 0.184*, 0.746

(0.592–0.941)

Myocardial infarction

1

0.067, 0.987

(0.783–1.245)

−0.121, 0.922

(0.624–1.363)

0.086, 0.965

(0.825–1.128)

−0.208*, 0.719

(0.549–0.943)

Stroke

1

0.002, 1.024

(0.882–1.189)

−0.033, 0.831

(0.639–1.082)

0.032, 0.961

(0.756–1.221)

− 0.105, 0.838

(0.559–1.256)

  1. Values represent odds ratios and 95% confidence intervals
  2. aHaplotypes of APOE, PVRL2, TOMM40, EXOC3L2, and CD3EAP in the 19q13 loci were generated by PLINK and it was divided into 3 categories (Major, Heterozygote and Minor haplotype groups) by the alleles (0, 1–2, and 3–4). The Major haplotype was the reference for both model 1 and model 2
  3. The cutoff points for dividing the values of each parameter into 2 groups were as follows: the control group included < 200 mg/dL for serum total cholesterol concentrationsb, < 160 mg/dL for serum LDL concentrations (LDL)c, ≥40 mg/dL for men and ≥ 50 mg/dL for women in serum HDL concentrations (HDL)d, < 150 mg/dL for serum triglyceride concentrationse and 2.85 for the ratio of serum LDL concentrations to serum HDL concentrationsf
  4. Model 1: adjusted for age, gender, residence area, body mass index, and energy intake
  5. Model 2: adjusted for the parameter in model 1 plus smoking, coffee, alcohol, physical activity, percent of fat and carbohydrate intakes, menopause, and serum total cholesterol concentrations
  6. * Significantly changed the risk of hyper-LDL-cholesterolemia by haplotype at P < 0.05, ** at P < 0.01, and *** at P < 0.0001
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