Contribution of CYP24A1 variants in coronary heart disease among the Chinese population

Table 2 Allele frequency of CYP24A1 SNPs and their associations with risk of CHD

SNP	Genotype	Location	Cases	Controls	MAF-Case	MAF-Control	HWE P	OR(95%CI)	P	HaploReg
rs2762934	A/G	3′-UTR	116/890	108/908	0.115	0.106	1.000	1.10 (0.83–1.45)	0.519	Enhancer histone marks, DNAse, Motifs, Proteins bound, Motifs changed
rs1570669	A/G	Intronic	379/629	401/615	0.376	0.395	0.403	0.92 (0.77–1.11)	0.388	DNAse, Proteins bound, Motifs changed, NHGRI/EBI GWAS hits
rs6068816	T/C	Synonymous	380/622	330/680	0.379	0.327	0.920	1.26 (1.05–1.51)	0.014	SiPhy cons, DNAse, Proteins bound, Motifs changed,
rs2296241	A/G	Synonymous	423/587	469/547	0.419	0.462	0.212	0.84 (0.71–1.00)	0.052	SiPhy cons, Enhancer histone marks, DNAse, Proteins bound, Motifs changed, Selected eQTL hits

SNP single nucleotide polymorphism, CHD coronary heart disease, MAF minor allele frequency, OR odds ratio, 95% CI 95% confidence interval
Bold-faced values indicate significant difference (P < 0.05)

ISSN: 1476-511X