From: Contribution of CYP24A1 variants in coronary heart disease among the Chinese population
SNP | Genotype | Cases | Controls | Without adjustment | With adjustment | ||
---|---|---|---|---|---|---|---|
OR(95%CI) | Pa | OR(95%CI) | Pb | ||||
rs2762934 | |||||||
co-dominant | AA | 4 | 5 | 0.83 (0.22–3.11) | 0.781 | 0.80 (0.21–3.02) | 0.745 |
GA | 108 | 98 | 1.14 (0.84–1.55) | 0.398 | 1.13 (0.83–1.54) | 0.436 | |
GG | 391 | 405 | 1 | 1 | |||
dominant | AA-AG | 112 | 103 | 1.13 (0.83–1.52) | 0.439 | 1.11 (0.82–1.51) | 0.484 |
GG | 391 | 405 | 1 | 1 | |||
recessive | AA | 4 | 5 | 0.81 (0.22–3.02) | 0.750 | 0.78 (0.21–2.94) | 0.716 |
AG-GG | 499 | 503 | 1 | 1 | |||
additive | 1.1 (0.83–1.46) | 0.512 | 1.09 (0.82–1.44) | 0.563 | |||
rs1570669 | |||||||
co-dominant | AA | 75 | 74 | 0.92 (0.63–1.34) | 0.655 | 0.91 (0.62–1.33) | 0.637 |
GA | 229 | 253 | 0.82 (0.63–1.07) | 0.146 | 0.82 (0.63–1.07) | 0.150 | |
GG | 200 | 181 | 1 | 1 | |||
dominant | AA-AG | 304 | 327 | 0.84 (0.65–1.09) | 0.184 | 0.84 (0.65–1.09) | 0.184 |
GG | 200 | 181 | 1 | 1 | |||
recessive | AA | 75 | 74 | 1.03 (0.72–1.45) | 0.888 | 1.02 (0.72–1.44) | 0.914 |
AG-GG | 429 | 434 | 1 | 1 | |||
additive | 0.92 (0.77–1.11) | 0.386 | 0.92 (0.77–1.10) | 0.378 | |||
rs6068816 | |||||||
co-dominant | TT | 74 | 53 | 1.63 (1.09–2.44) | 0.017 | 1.64 (1.10–2.46) | 0.015 |
TC | 232 | 224 | 1.21 (0.93–1.58) | 0.157 | 1.21 (0.93–1.58) | 0.152 | |
CC | 195 | 228 | 1 | 1 | |||
dominant | TT-TC | 306 | 277 | 1.29 (1.01–1.66) | 0.046 | 1.30 (1.01–1.67) | 0.043 |
CC | 195 | 228 | 1 | 1 | |||
recessive | TT | 74 | 53 | 1.48 (1.01–2.15) | 0.042 | 1.49 (1.02–2.17) | 0.040 |
TC-CC | 427 | 452 | 1 | 1 | |||
additive | 1.26 (1.05–1.51) | 0.014 | 1.26 (1.05–1.52) | 0.013 | |||
rs2296241 | |||||||
co-dominant | AA | 71 | 101 | 0.64 (0.44–0.94) | 0.023 | 0.63 (0.43–0.93) | 0.019 |
GA | 281 | 267 | 0.96 (0.73–1.28) | 0.795 | 0.95 (0.71–1.26) | 0.702 | |
GG | 153 | 140 | 1 | 1 | |||
dominant | AA-AG | 352 | 368 | 0.88 (0.67–1.15) | 0.337 | 0.86 (0.65–1.13) | 0.280 |
GG | 153 | 140 | 1 | 1 | |||
recessive | AA | 71 | 101 | 0.66 (0.47–0.92) | 0.014 | 0.66 (0.47–0.92) | 0.013 |
AG-GG | 434 | 407 | 1 | 1 | |||
additive | 0.82 (0.68–0.99) | 0.041 | 0.82 (0.68–0.98) | 0.033 |