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Table 3 Genotypes frequencies of CYP24A1 SNPs and their associations with risk of CHD

From: Contribution of CYP24A1 variants in coronary heart disease among the Chinese population

SNP

Genotype

Cases

Controls

Without adjustment

With adjustment

OR(95%CI)

Pa

OR(95%CI)

Pb

rs2762934

 co-dominant

AA

4

5

0.83 (0.22–3.11)

0.781

0.80 (0.21–3.02)

0.745

GA

108

98

1.14 (0.84–1.55)

0.398

1.13 (0.83–1.54)

0.436

GG

391

405

1

 

1

 

 dominant

AA-AG

112

103

1.13 (0.83–1.52)

0.439

1.11 (0.82–1.51)

0.484

GG

391

405

1

 

1

 

 recessive

AA

4

5

0.81 (0.22–3.02)

0.750

0.78 (0.21–2.94)

0.716

AG-GG

499

503

1

 

1

 

 additive

   

1.1 (0.83–1.46)

0.512

1.09 (0.82–1.44)

0.563

 rs1570669

       

 co-dominant

AA

75

74

0.92 (0.63–1.34)

0.655

0.91 (0.62–1.33)

0.637

GA

229

253

0.82 (0.63–1.07)

0.146

0.82 (0.63–1.07)

0.150

GG

200

181

1

 

1

 

 dominant

AA-AG

304

327

0.84 (0.65–1.09)

0.184

0.84 (0.65–1.09)

0.184

GG

200

181

1

 

1

 

 recessive

AA

75

74

1.03 (0.72–1.45)

0.888

1.02 (0.72–1.44)

0.914

AG-GG

429

434

1

 

1

 

 additive

   

0.92 (0.77–1.11)

0.386

0.92 (0.77–1.10)

0.378

rs6068816

 co-dominant

TT

74

53

1.63 (1.09–2.44)

0.017

1.64 (1.10–2.46)

0.015

TC

232

224

1.21 (0.93–1.58)

0.157

1.21 (0.93–1.58)

0.152

CC

195

228

1

 

1

 

 dominant

TT-TC

306

277

1.29 (1.01–1.66)

0.046

1.30 (1.01–1.67)

0.043

CC

195

228

1

 

1

 

 recessive

TT

74

53

1.48 (1.01–2.15)

0.042

1.49 (1.02–2.17)

0.040

TC-CC

427

452

1

 

1

 

 additive

   

1.26 (1.05–1.51)

0.014

1.26 (1.05–1.52)

0.013

rs2296241

 co-dominant

AA

71

101

0.64 (0.44–0.94)

0.023

0.63 (0.43–0.93)

0.019

GA

281

267

0.96 (0.73–1.28)

0.795

0.95 (0.71–1.26)

0.702

GG

153

140

1

 

1

 

 dominant

AA-AG

352

368

0.88 (0.67–1.15)

0.337

0.86 (0.65–1.13)

0.280

GG

153

140

1

 

1

 

 recessive

AA

71

101

0.66 (0.47–0.92)

0.014

0.66 (0.47–0.92)

0.013

AG-GG

434

407

1

 

1

 

 additive

   

0.82 (0.68–0.99)

0.041

0.82 (0.68–0.98)

0.033

  1. SNP single nucleotide polymorphism, CHD coronary heart disease, OR odds ratio, 95% CI 95% confidence interval
  2. Pa values were calculated by logistic regression analysis with the comparison between CHD patients and healthy controls
  3. Pb values were calculated by logistic regression analysis with adjustment for age and gender
  4. Bold-faced values indicate significant difference (P <  0.05)