Table 4 Stratification analyses of the association of CYP24A1 polymorphisms with susceptibility of CHD
From: Contribution of CYP24A1 variants in coronary heart disease among the Chinese population
Polymorphisms | Subgroups | Homozygote | Heterozygote | Dominant | Recessive | Additive | Allele | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | ||
rs2762934 | Age (≤ 60) | – | – | 1.51 (0.93–2.44) | 0.090 | 1.57 (0.97–2.53) | 0.060 | – | – | 1.61 (1.01–2.56) | 0.040 | 1.57 (1.00–2.46) | 0.048 |
rs1570669 | Gensini grade | 0.61 (0.31–1.20) | 0.156 | 1.79 (1.06–3.02) | 0.031 | 1.33 (0.82–2.14) | 0.243 | 1.45 (0.24–0.85) | 0.013 | 0.92 (0.66–1.29) | 0.637 | 0.90 (0.64–1.26) | 0.544 |
rs6068816 | Age (≤ 60) | 2.76 (1.47–5.20) | < 0.001 | 1.27 (0.85–1.90) | 0.250 | 1.49 (1.01–2.18) | 0.040 | 2.42 (1.34–4.38) | < 0.001 | 1.53 (1.15–2.03) | < 0.001 | 1.51 (1.15–1.99) | 0.003 |
Men | 2.03 (1.21–3.40) | 0.007 | 1.30 (0.94–1.80) | 0.116 | 1.42 (1.04–1.93) | 0.028 | 1.77 (1.09–2.88) | 0.022 | 1.38 (1.10–1.74) | 0.006 | 1.37 (1.09–1.72) | 0.007 | |
Smoker | 3.02 (1.31–6.99) | 0.010 | 1.33 (0.82–2.16) | 0.251 | 1.56 (0.98–2.49) | 0.060 | 2.60 (1.17–5.78) | 0.019 | 1.57 (1.11–2.23) | 0.011 | 1.61 (1.15–2.27) | 0.006 | |
rs2296241 | Men | 0.60 (0.37–0.96) | 0.031 | 0.77 (0.54–1.09) | 0.140 | 0.73 (0.52–1.01) | 0.059 | 0.71 (0.47–1.07) | 0.099 | 0.77 (0.61–0.97) | 0.027 | 1.25 (0.16–1.90) | 0.180 |