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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Quercetin attenuates reduced uterine perfusion pressure -induced hypertension in pregnant rats through regulation of endothelin-1 and endothelin-1 type A receptor

Fig. 5

Comparison of the effect of quercetin with the activity of the ETAR antagonist BQ-123 on blood pressure and outcomes in RUPP rats. BQ-123 abolishes the increase in systolic (a) and diastolic (b) blood pressure. Values were measured at day 19 of gestation. Fetal resorptions (c), fetal body weight (d), placental weight (e) and fetal/placental weight ratio (f) and were determined in pregnant rats at day 21 of gestation. n = 6 for each group in (a-c), n = 53, 26, 29 and 45 pups in control, RUPP, RUPP+Quercetin (50 mg/kg) and RUPP+BQ-123 group respectively in (d-f). Data were shown as mean ± SD. *P < 0.05 compared with the Control group; &P < 0.05 compared with the RUPP group. One-way ANOVA with a Tukey’s post hoc test (a, b, d-f), Kruskal-Wallis test (c)

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