Skip to main content

Table 2 CpG site methylation of candidate genes between two groups

From: TBL2 methylation is associated with hyper-low-density lipoprotein cholesterolemia: a case-control study

CpG region

CpG site

Methylation levels (median %, minimum - maximum)

P value

With Hyper-LDL

Without Hyper-LDL

TBL2–1

37

1.45 (0.76–1.94)

1.37 (0.67–2.68)

0.027

TBL2–2

33

13.42 (11.34–15.05)

13.7 (12–15.27)

0.005

37

11.23 (9.17–13.14)

11.58 (8.54–13.49)

0.032

89

26.80 (22.44–32.06)

27.78 (22.14–31.03)

0.0004

TBL2–3

40

2.13 (1.08–3.42)

1.91 (0–6.67)

0.0004

50

2.03 (1.18–3.14)

1.77 (0–3.18)

0.0001

54

2.49 (1.21–4.01)

2.33 (0–10.00)

0.042

65

1.44 (0.67–2.46)

1.35 (0–3.12)

0.015

74

1.47 (0.87–2.71)

1.38 (0–2.85)

0.009

78

1.64 (0.88–2.52)

1.50 (0–2.98)

0.028

88

1.23 (0.55–2.02)

1.13 (0–14.29)

0.004

135

0.84 (0.20–2.01)

0.72 (0–4.00)

0.023

144

0.74 (0.16–1.76)

0.67 (0–5.00)

0.036

HMGCR-1

116

0.83 (0–1.81)

0.70 (0–2.67)

0.028

HMGCR-2

51

0.68 (0.19–1.68)

0.62 (0.17–2.12)

0.019

55

0.86 (0.35–1.62)

0.95 (0.36–2.18)

0.009

HMGCR-3

37

0.51 (0–1.75)

0.64 (0–1.57)

0.013

182

1.09 (0–2.56)

0.90 (0–6.36)

0.006

SCAP

33

0.00 (0–6.67)

0.00 (0–10)

0.005

SREBF1–1

19

3.24 (0–5.21)

2.80 (0–5.56)

0.0001

25

0.72 (0–2.25)

0.55 (0–3.96)

0.014

36

0.74 (0–2.06)

0.60 (0–2.12)

0.012

SREBF1–2

154

0.79 (0–2.44)

1.00 (0–3.26)

0.006

SREBF1–3

28

0.49 (0–2.42)

0.30 (0–3.19)

0.006

SREBF2–1

101

7.74 (0–11.01)

7.53 (4.24–10.64)

0.021

SREBF2–2

123

0.92 (0.08–2.6)

0.79 (0–2.86)

0.039

157

2.60 (0.96–5.01)

2.19 (0–6.88)

0.004

SREBF2–3

112

1.23 (0.12–3.17)

0.96 (0–3.18)

0.003

213

1.13 (0.15–2.98)

0.92 (0–3.9)

0.012

  1. HMGCR HMG-CoA reductase, SREBF Sterol regulatory element-binding transcription factors, SCAP SREBF cleavage activator protein, TBL2 Transducin (β)-like 2
Back to article page

Lipids in Health and Disease

ISSN: 1476-511X