Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis

Table 5 Predictors for the occurrence of CVA during follow-up

Variables	Univariable			Multivariable
Variables	HR	95% CI	P-value	HR	95% CI	P-value
Demographic data
Age (years)	1.027	0.982, 1.074	0.243
Male gender	0.862	0.259, 2.874	0.809
Body mass index (kg/m²)	0.991	0.826, 1.190	0.924
Smoking history	0.047	0.000, 32,787.590	0.656
Comorbidities
Chronic kidney disease (stage 3–5)	1.069	0.322, 3.551	0.914
Diabetes mellitus	1.527	0.484, 4.810	0.470
Hypertension	1.636	0.492, 5.442	0.422
ANCA positivity
MPO-ANCA (or P-ANCA) positivity	0.678	0.215, 2.142	0.508
PR3-ANCA (or C-ANCA) positivity	1.041	0.228, 4.760	0.958
AAV-specific indices
BVAS	1.074	0.995, 1.160	0.066
FFS	1.476	0.851, 2.559	0.165
Acute phase reactants
ESR (mm/hr)	1.001	0.986, 1.017	0.860
CRP (mg/L)	1.008	1.001, 1.016	0.035
AIP ≥ 0.11	3.391	1.075, 10.695	0.037	3.392	1.076, 10.696	0.037

CVA Cerebrovascular accident, ANCA Antineutrophil cytoplasmic antibody, MPO Myeloperoxidase, P Perinuclear, PR3 Proteinase 3, C Cytoplasmic, BVAS Birmingham vasculitis activity score, FFS Five factor score, ESR Erythrocyte sedimentation rate, CRP C-reactive protein, AIP Atherogenic index of plasma

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