Circulating FABP4, nesfatin-1, and osteocalcin concentrations in women with gestational diabetes mellitus: a meta-analysis

Sun, Jianran; Zhang, Dai; Xu, Jiang; Chen, Chao; Deng, Datong; Pan, Faming; Dong, Lin; Li, Sumei; Ye, Shandong

doi:10.1186/s12944-020-01365-w

Lipids in Health and Disease

Table 1 Characteristics of studies analyzing circulating FABP4, nesfatin-1, and OC concentrations in women with GDM

From: Circulating FABP4, nesfatin-1, and osteocalcin concentrations in women with gestational diabetes mellitus: a meta-analysis

				Cases					Controls
First authors	Year	Country	Study type	N	Age (years) mean ± SD	Gestational BMI(kg/m²)	Mean ± SD (ng/mL)/(ng/mL)	N	Age (years) mean ± SD	Gestational BMI(kg/m²)	Mean ± SD (ng/mL)/(ng/mL)	P	Criteria for GDM	Measurement	NOS
FABP4
Zhang et al. [18]	2016	China	CC	40	26.91 ± 2.24	27.55 ± 3.40	32.35 ± 3.06	240	27.83 ± 2.65	24.31 ± 2.92	22.01 ± 2.00	< 0.01	IADPSG	ELISA system)	7
Zhang et al. [18]	2016	China	CC	40	38.73 ± 1.43	28.91 ± 3.36	51.79 ± 4.64	240	38.56 ± 1.28	26.29 ± 3.75	39.35 ± 3.59	< 0.05	IADPSG	ELISA	7
Malysza et al. [8]	2019	Poland	CC	26	35.93 ± 3.77	27.28 ± 2.21	18.64 ± 4.59	28	30.43 ± 5.85	21.48 ± 2.05	11.07 ± 3.90	0.00022	IADPSG	ELISA	8
Herrera et al. [28]	2011	Spain	CC	98	30.90 ± 0.50	27.30 ± 0.50	19.90 ± 1.00	86	28.70 ± 0.50	25.40 ± 0.60	17.70 ± 0.80	0.0493	C&C	ELISA	8
Li et al. [19]	2015	China	CC	30	31.83 ± 3.91	21.80 ± 1.02	1.47 ± 0.25	30	26.53 ± 1.91	19.18 ± 0.68	0.20 ± 0.07	< 0.0001	IADPSG	ELISA	6
Guelfi et al. [17]	2017	Australia	Cohort	52	33.50 ± 4.00	26.10 ± 5.50	2.77 ± 1.04	71	33.50 ± 4.00	26.10 ± 5.50	2.21 ± 0.55	> 0.05	ADIPS	ELISA	6
Kralisch et al. [26]	2009	Germany	CC	40	33.00 ± 10.00	24.90 ± 4.90	22.90 ± 12.20	80	28.00 ± 5.00	22.30 ± 7.00	18.30 ± 12.90	< 0.05	ADIPS	ELISA	7
Zhang et al. [11]	2017	China	CC	50	31.78 ± 4.81	22.11 ± 3.69	20.00 ± 10.38	50	30.16 ± 4.46	21.10 ± 2.99	10.50 ± 5.69	< 0.001	IADPSG	ELISA	8
Zhang et al. [29]	2011	China	CC	30	28.50 ± 1.90	29.30 ± 1.10	32.71 ± 1.93	30	27.50 ± 1.60	27.60 ± 1.30	21.42 ± 1.87	< 0.05	NDDG	ELISA	7
Dong et al. [27]	2011	China	CC	20	29.00 ± 2.00	21.88 ± 1.94	1.05 ± 0.33	20	27.50 ± 3.00	21.02 ± 2.20	0.83 ± 0.33	0.002	ACOG	ELISA	6
Dong et al. [27]	2011	China	CC	20	26.50 ± 9.00	26.38 ± 1.65	1.26 ± 0.08	20	27.50 ± 3.00	21.02 ± 2.20	0.83 ± 0.33	< 0.05	ACOG	ELISA	6
Zang et al. [36]	2019	China	CC	52	28.87 ± 2.03	29.03 ± 1.08	32.80 ± 1.89	52	28.42 ± 2.07	27.78 ± 1.29	22.38 ± 1.86	< 0.05	ADA	ELISA	7
Ma et al. [46]	2016	China	CC	60	28.40 ± 4.30	24.50 ± 1.50	27.49 ± 3.72	30	28.90 ± 3.60	23.40 ± 1.20	18.98 ± 5.51	0.007	ADA	ELISA	7
Chen et al. [35]	2019	China	CC	42	30.45 ± 4.21	26.73 ± 1.86	28.63 ± 4.06	36	31.24 ± 4.37	21.73 ± 2.46	17.47 ± 4.21	< 0.001	IADPSG	ELISA	7
Li et al. [34]	2019	China	CC	100	27.30 ± 3.00	26.20 ± 2.00	32.67 ± 3.94	100	27.40 ± 2.80	26.00 ± 1.80	22.85 ± 2.88	< 0.001	ADA	ELISA	7
Ye et al. [33]	2017	China	CC	35	27.00 ± 1.80	26.60 ± 2.10	31.70 ± 1.70	35	26.80 ± 1.10	20.90 ± 3.10	20.40 ± 1.70	< 0.01	ACOG	ELISA	7
Dang et al. [47]	2017	China	CC	60	29.50 ± 3.70	23.40 ± 1.50	27.39 ± 3.58	60	29.80 ± 3.60	23.70 ± 1.80	18.41 ± 3.62	< 0.001	ADA	ELISA	6
Zhang et al. [30]	2012	China	CC	50	29.20 ± 3.40	24.70 ± 3.50	29.80 ± 2.40	46	29.80 ± 2.90	22.10 ± 3.60	18.90 ± 1.90	< 0.05	NDDG	ELISA	7
Shen et al. [32]	2017	China	CC	50	28.60 ± 3.50	24.50 ± 1.50	35.11 ± 11.32	40	28.10 ± 4.40	23.70 ± 1.60	21.14 ± 8.75	0.008	ADA	ELISA	7
Nesfatin-1
Mehmet et al. [38]	2012	Turkey	CC	30	30.90 ± 4.20	25.90 ± 3.30	5.50 ± 8.10	30	31.00 ± 3.20	25.70 ± 2.80	8.10 ± 23.90	0.001	ACOG	ELISA	8
Kucukler et al. [20]	2016	Turkey	CC	38	32.10 ± 6.20	33.80 ± 6.50	7.54 ± 1.40	41	26.80 ± 5.70	26.50 ± 5.00	8.32 ± 1.09	0.013	ADA	ELISA	6
Mierzynski et [10]	2019	Poland	CC	153	27.59 ± 4.87	26.63 ± 2.11	5.15 ± 3.51	84	27.23 ± 4.67	26.13 ± 1.71	6.69 ± 4.21	< 0.01	WHO	ELISA	7
Zhang et al. [11]	2017	China	CC	50	31.78 ± 4.81	22.11 ± 3.69	1.74 ± 0.52	50	30.16 ± 4.46	21.10 ± 2.99	1.37 ± 0.50	0.004	IADPSG	ELISA	8
Ademoglu et al. [12]	2017	Turkey	CC	40	29.60 ± 5.30	31.00 ± 5.50	7.90 ± 2.80	30	27.80 ± 6.00	28.20 ± 1.50	11.20 ± 7.70	0.020	C&C	ELISA	7
Aydin et al. [37]	2010	Turkey	CC	10	29.10 ± 2.20	33.20 ± 4.80	6.60 ± 2.00	10	28.20 ± 1.80	31.98 ± 4.40	7.80 ± 3.00	< 0.05	ADA	ELISA	6
Ma et al. [46]	2016	China	CC	60	28.40 ± 4.30	24.50 ± 1.50	2.49 ± 0.72	30	28.90 ± 3.60	23.40 ± 1.20	1.98 ± 0.51	< 0.05	ADA	ELISA	7
Zhu et al. [40]	2017	China	CC	15	29.75 ± 5.16	24.05 ± 3.61	8.10 ± 1.50	40	27.92 ± 4.57	23.68 ± 3.49	12.80 ± 3.20	< 0.05	ADA	ELISA	7
Zhu et al. [40]	2017	China	CC	25	27.96 ± 4.37	23.32 ± 3.51	9.80 ± 2.60	40	27.92 ± 4.57	23.68 ± 3.49	12.80 ± 3.20	< 0.05	ADA	ELISA	7
Xu et al. [39]	2017	China	CC	55	31.50 ± 7.20	NA	2.13 ± 0.95	210	31.50 ± 7.20	NA	1.35 ± 0.75	0.015	ADA	ELISA	6
Dang et al. [47]	2017	China	CC	60	29.50 ± 3.70	23.40 ± 1.50	2.49 ± 0.61	60	29.80 ± 3.60	23.70 ± 1.80	1.97 ± 0.56	< 0.001	ADA	ELISA	6
OC
Srichomkwun [21]	2015	Thailand	CC	74	34.00 ± 5.00	23.10 ± 2.28	6.22 ± 2.70	56	32.00 ± 5.00	22.78 ± 2.16	4.86 ± 2.85	0.267	ADA	ELISA	7
Srichomkwun [21]	2015	Thailand	CC	74	34.00 ± 5.00	23.10 ± 2.28	12.86 ± 4.10	56	32.00 ± 5.00	22.78 ± 2.16	11.18 ± 3.20	0.527	ADA	ECLIA	7
Winhofer et al. [14]	2010	Austria	CC	26	33.00 ± 6.00	27.80 ± 4.80	15.60 ± 6.40	52	32.00 ± 6.00	28.00 ± 5.10	12.60 ± 4.00	0.0146	ADA	ECLIA	7
Zarate et al. [41]	2015	Mexico	CC	60	30.40 ± 4.40	33.30 ± 4.60	15.10 ± 4.65	60	27.90 ± 5.10	27.80 ± 4.80	17.48 ± 4.15	0.610	ADA	IRMA	8
Zarate et al. [41]	2015	Mexico	CC	60	30.40 ± 4.40	33.30 ± 4.60	2.90 ± 1.44	60	27.90 ± 5.10	27.80 ± 4.80	2.03 ± 1.37	0.758	ADA	ELISA	8
Li et al. [42]	2015	China	CC	30	28.50 ± 3.20	20.20 ± 1.50	14.95 ± 4.16	30	27.90 ± 3.00	20.30 ± 1.50	12.65 ± 3.09	0.017	ADA	ECLIA	6
Zuo et al. [44]	2018	China	CC	31	25.55 ± 1.73	25.03 ± 1.24	11.12 ± 1.56	30	25.50 ± 1.74	25.38 ± 1.33	10.44 ± 0.73	< 0.05	ADA	ELISA	7
Zuo et al. [44]	2018	China	CC	31	25.55 ± 1.73	25.03 ± 1.24	5.36 ± 0.83	30	25.50 ± 1.74	25.38 ± 1.33	5.27 ± 0.39	< 0.05	ADA	ELISA	7
Zuo et al. [44]	2018	China	CC	32	25.34 ± 1.75	25.03 ± 0.81	14.34 ± 1.03	30	25.50 ± 1.74	25.38 ± 1.33	10.44 ± 0.73	< 0.05	ADA	ELISA	7
Zuo et al. [44]	2018	China	CC	32	25.34 ± 1.75	25.03 ± 0.81	5.56 ± 0.46	30	25.50 ± 1.74	25.38 ± 1.33	5.27 ± 0.39	< 0.05	ADA	ELISA	7
Feng et al. [45]	2019	China	NCC	89	28.31 ± 3.42	22.42 ± 3.72	8.94 ± 2.59	89	27.16 ± 3.06	20.70 ± 2.48	7.60 ± 1.55	< 0.001	ADA	ECLIA	7
Niu et al. [43]	2018	China	CC	89	28.31 ± 3.42	25.08 ± 1.25	11.98 ± 4.49	89	27.16 ± 3.06	24.85 ± 0.97	9.64 ± 1.90	< 0.001	ADA	ECLIA	7

N Number of subjects, GDM Gestational diabetes mellitus, CC Case control, NCC Nested case–control, BMI Body mass index, ADA American diabetes association, ACOG American College of Obstetricians and Gynecologists, C&C Carpenter and Couston, WHO World Health Organization, IADPSG International Association of Diabetes and Pregnancy Study Group, ADIPS Australasian Diabetes in Pregnancy Society, NDDG National Diabetes Date Group, ELASA Enzyme linked immunosorbent assay, IRMA Immunoradiometric assay, ECLIA Electrochemiluminescence immunoassay, NOS Newcastle-Ottawa Scale, NA Not available

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