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Table 5 Association of CYP19A1 and CYP1A2 haplotypes with T2DM risk

From: Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population

Subgroup

Gene

SNP

Haplotype

Fre-case

Fre-control

OR(95% CI)

P

Overall

CYP19A1

rs17601876|rs3751599

GA

0.058

0.074

0.76(0.53–1.09)

0.136

AG

0.341

0.334

1.03(0.86–1.24)

0.744

GG

0.398

0.408

0.96(0.81–1.15)

0.666

CYP1A2

rs762551|rs2470890

AT

0.120

0.114

1.07(0.81–1.40)

0.640

CC

0.401

0.413

0.95(0.79–1.14)

0.586

AC

0.478

0.473

1.02(0.86–1.21)

0.825

Diabetic retinopathy

CYP19A1

rs1062033|rs17601876|rs3751599

CGA

0.042

0.081

0.48(0.25–0.91)

0.026*

CAG

0.330

0.352

0.90(0.65–1.23)

0.509

GGG

0.429

0.409

1.05(0.79–1.41)

0.725

CGG

0.196

0.151

1.45(0.97–2.18)

0.072

  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. P value was calculated by logistic regression analysis with adjustment for age and gender
  3. *P < 0.05 indicates statistical significance