Fig. 2From: Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s diseaseAnalysis of the fatty acid species in the PLBWT and PLB4 brain. The relative abundance of each fatty acid methyl ester (FAME) identified in the cortex (A), hippocampus (B), and hypothalamus (C) was normalised to C15:0 as the internal standard. Annotation of the major FAME species were identified from MS daughter ion fragmentation scans. Data represented as average ± S.E.M (n = 6). The normalised abundance (arbitrary units) refers to the normalised total ion count for individual molecular species. An unpaired, two-tailed Student’s t-test with Welch’s correction was performed to determine statistically significant differences between PLBWT and PLB4 data. * P ≤ 0.05, ** P ≤ 0.01; hippocampus FAMEs - C16:1 P = 0.0325, C16:0 P = 0.0112, C18:0 P = 0.0204, C20:3 n-6 P = 0.0060Back to article page