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Table 1 Summary of the lipid alterations in the PLB4 cortex, hippocampus, and hypothalamus. Lipid species listed by class showing the most the statistically significant alterations in the PLB4 brain compared to PLBWT. An unpaired, two-tailed Student’s T-test with Welch’s correction was performed to determine statistically significant differences between PLBWT and PLB4 lipid species and brain regions: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. Abbreviations: PE – phosphatidylethanolamine, PC – phosphatidylcholine, PI – phosphatidylinositol, TG – triacylglycerol, DG – diacylglycerol, PS – phosphatidylserine, Cer – ceramide, SM – sphingomyelin, PG – phosphatidylglycerol

From: Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease