Fig. 1

LI85008F regulates body weight and reduces body weight gain in high-fat diet-fed obese rats. a The bar graph shows changes in body weights (mean ± SD) of Sprague Dawley rats receiving regular diet (RD; n = 7) or a high-fat diet (HFD; n = 21) for 28 days of the induction phase of the study. b The bar graph presents the effect of LI85008F supplementation on the body weights of the experimental rats during the 28-day supplementation period (from day 29 through day 56). Body weights measured weekly, and the data present the mean ± SD of body weights (n = 7). The rats received either a regular diet (RD) or a high-fat diet (HFD) or HFD in combination with a daily dose of 100 mg/kg (LI85008F-100) or 250 mg/kg (LI85008F-250) LI85008F, as described in the Materials and Methods. c The bar diagram presents the mean ± SD of percent changes (from day 29) in body weight (BW) at day 56. *, # and $ indicate significance (P < 0.05) in RD vs. HFD, HFD vs. LI85008F-100, and HFD vs. LI85008F-250 comparison analysis, respectively using one-way ANOVA