Lipids in Health and Disease

Table 2 Anthropometric and clinical data of control subjects and individuals with DKD categorized according to the estimated glomerular filtration rate (eGFR; mL/min/1.73 m²) and albumin excretion rate (AER; A1 = normoalbuminuria, A2 = microalbuminuria; A3 = macroalbuminuria)

From: Enrichment of apolipoprotein A-IV and apolipoprotein D in the HDL proteome is associated with HDL functions in diabetic kidney disease without dialysis

	Control eGFR > 60	DKD eGFR > 60 A1 + A2	DKD eGFR < 60 A3
n (F/M)	8 (4/4)	10 (7/3)	25 (7/18)
Age (years)	68.5 (58–84)	68 (53–75)	69 (55–87)
eGFR (mL/min/1.73m²)	84.5 (63–102)	82.0 (61–131)	25 (10–46)^#
AER (mg/g creatinine)	–	9.5 (2.4–114)	1128 (317–6430)^@
Time of DM (years)	–	14 (4–26)	18 (6–30)
CVD history (%)	–	2 (20%)	11 (44%)
BMI (kg/m²)	24.9 (21–29)	33 (25–45) *	27 (21–38)
HbA1c (%)	5.6 (5.0–6.0)	8.4 (7.0–8.0)^#	8.3 (6.0–10.0) ^#
Fructosamine (μmol/L)	219 (205–262)	308 (158–428)^&	331 (329–506) ^&
TC (mg/dL)	208 (155–290)	144 (114–186)^$	154 (92–313)
TG (mg/dL)	111 (71–362)	88 (64–151)	148 (78–329)
HDLc (mg/dL)	49 (33–87)	46 (35–92)	40 (21–140)
CML (μg/mL)	0.5 (0.3–1.0)	1.7 (0.5–3.4)	1.0 (0.7–7.3)

BMI body mass index, HbA1c glycated hemoglobin, TC total cholesterol, TG triglycerides, HDLc HDL cholesterol, CML carboxymethyl-lysine. Results were compared by the Kruskal-Wallis test with Holm-Sidak posttest (median - range); * p < 0.004; ^# p < 0.0001; ^& p < 0.001 and ^$ p < 0.006 in comparison to Control GFR > 60, and by Mann- Whitney test; @ p < 0.001 in comparison to eGFR > 60 A1 + A2

Back to article page

ISSN: 1476-511X

Contact us

General enquiries: journalsubmissions@springernature.com