Fig. 4From: Signaling and other functions of lipids in autophagy: a reviewPPARγ mediated activation of autophagy. PPARγ promotes the expression of PTEN. High amounts of PTEN lead to lower concentrations of PI(3,4,5)P3. Less PI(3,4,5)P3 inhibits the activation of PDK1 and ultimately results in inhibition of mTORC1 which causes an activation of autophagyBack to article page