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Table 2 Biochemical analyses compared between users and non-users of LLD and AHD

From: Higher levels of the soluble receptor for advanced glycation end products and lower levels of the extracellular newly identified receptor for advanced glycation end products were associated with lipid-lowering drugs in patients with type 1 diabetes: a comparative cross-sectional study

 

All patients a

Users of lipid-lowering drugs b

Users of antihypertensive drugs

Yes

No

P value c

Yes

No

P value c

N

283

130

153

–

89

194

–

EN-RAGE d, μg/L

(1.5–907)

11.8 (6.8, 18.8)

13.7 (8.0, 24.9)

0.060

12.8 (7.0, 18.9)

13.2 (7.4, 23.4)

0.48

sRAGE e, μg/L

(0.2–105)

1.3 (0.8, 2.0)

1.3 (0.8, 1.8)

0.38

1.1 (0.6, 1.7)

1.3 (0.9, 1.9)

0.031

EN-RAGE/sRAGE ratio f

(0.4–756)

7.9 (4.0, 17.7)

11.7 (6.7, 22.8)

0.009

10.8 (4.5, 29.4)

10.0 (5.3, 17.4)

0.19

CRP g, mg/L

(0.03–8.9)

0.5 (0.2, 1.7)

0.8 (0.3, 1.6)

0.67

0.6 (0.3, 1.7)

0.7 (0.3, 1.7)

0.86

HbA1c

 mmol/mol

(25–110)

64 (56, 72)

61 (53, 69)

0.022

65 (55, 72)

60 (54, 71)

0.090

 %

(4.4–12.2)

8.0 (7.3, 8.7)

7.8 (7.0, 8.5)

8.1 (7.2, 8.8)

7.7 (7.1, 8.6)

Total cholesterol, mmol/L

(2.1–10.9)

4.5 (4.0, 5.2)

4.6 (4.1, 5.2)

0.37

4.7 (4.0, 5.3)

4.6 (4.1, 5.1)

0.69

Triglycerides, mmol/L

(0.1–5.9)

1.0 (0.7, 1.3)

0.8 (0.7, 1.1)

0.016

1.0 (0.7, 1.4)

0.9 (0.6, 1.2)

0.043

LDL-cholesterol, mmol/L

(0.6–8.3)

2.7 (2.3, 3.3)

2.9 (2.4, 3.3)

0.12

2.8 (2.3, 3.4)

2.8 (2.4, 3.3)

0.98

HDL-cholesterol, mmol/L

(0.3–2.7)

1.5 (1.3, 1.8)

1.5 (1.3, 1.8)

0.52

1.5 (1.3, 1.8)

1.5 (1.3, 1.8)

0.60

S-creatinine h, μmol/L

(28–182)

71 (64, 80)

69 (61, 76)

0.088

72 (63, 81)

69 (61, 77)

0.022

  1. a Data are presented as (min-max). b Data are presented as median (q1, q3). c Mann-Whitney U test unless indicated
  2. Missing values (N): d 18; e 14; f 22; g 109 h 12